Platelet-rich plasma for androgenetic alopecia: A review of the literature and proposed treatment protocol

International Journal of Women's Dermatology
J Stevens, S Khetarpal

Abstract

Androgenetic alopecia (AGA) is a common hair loss disorder caused by genetic and hormonal factors that are characterized by androgen-related progressive thinning of scalp hair in a defined pattern. By the age of 60 years, 45% of men and 35% of women develop AGA. Currently, U.S. Food and Drug Administration-approved treatments for AGA include oral finasteride and topical minoxidil. Due to the limited number of effective therapies for AGA, platelet-rich plasma (PRP) has become an effective alternative treatment. PRP is an autologous concentration of platelets in plasma with numerous growth factors that contribute to hair regeneration. The growth factors contained within the alpha granules of platelets act on stem cells in the bulge area of the hair follicles and stimulate the development of new follicles along with neovascularization. PRP has become a promising treatment modality for AGA. Although there have been several studies previously reported, a standard practice for PRP preparation and administration as well as a method to evaluate results have not been established. This literature review was conducted to evaluate the effectiveness of PRP for AGA and discuss the various treatment protocols that have been proposed.

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Citations

Aug 28, 2019·Journal of Cosmetic Dermatology·Gezim DervishiFrank Peinemann
Mar 13, 2020·Lasers in Medical Science·Hassan GaladariMohamad Goldust
Jun 20, 2020·Dermatology and Therapy·Rubina Alves, Ramon Grimalt
Jun 11, 2020·The Journal of Dermatological Treatment·Alfredo RossiMarta Carlesimo
Jun 27, 2020·Dermatologic Therapy·Pooneh TorabiMasoomeh Rohaninasab
May 22, 2020·European Journal of Clinical Pharmacology·Basile ChrétienSophie Fedrizzi
Jan 14, 2021·Journal of Cosmetic Dermatology·Wafaa Mohammad RamadanYasmina Ahmed El Attar
Dec 29, 2020·Plastic and Reconstructive Surgery·Edward S ChamataRod J Rohrich
Jun 24, 2021·The Journal of Dermatological Treatment·A K GuptaM A Bamimore
Jul 11, 2021·Indian Journal of Dermatology, Venereology and Leprology·K MuthuprabakaranPankaj Shukla
Apr 28, 2021·Journal of the American Academy of Dermatology·Francisco JimenezMarc Avram
Apr 8, 2020·Skin Appendage Disorders·Aline Lissa OkitaRachel Berbert Ferreira
Nov 11, 2021·Journal of the American Academy of Dermatology·Julia L GaoJon Klinton Peebles

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