Platelet-rich plasma for male genital lichen sclerosus resistant to conventional therapy: First prospective study

Dermatologic Therapy
Jorge NavarreteCristina Touriño

Abstract

Ultrapotent topical corticosteroids and circumcision are usually effective for male genital lichen sclerosus (MGLSc); however, refractory cases are often referred to our Male Genital Dermatology Unit. Treatment with autologous platelet-rich plasma (TPRP) has recently been advocated as a safe and effective treatment option, but there have been no prospective studies in men to date. The objective of this study is to assess the safety and efficacy of TPRP for MGLSc resistant to conventional therapy. A prospective, open-label, single-arm, therapeutic study was carried out in this study. Inclusion criteria: resistant to conventional therapy for at least 6 months. Procedure: infiltration of 0.1 mL/cm2 PRP every 8 weeks. Monthly data recording: visual appearance with photographs and external scoring by an expert using Investigator's Global Assessment Scale (IGA scale 0-5), symptoms (scale 0-5), quality of life (QoL; Dermatology Life Quality Index [DLQI]), and complications. No. of patients included was n = 5. No. of patients excluded during treatment was n = 1. Mean initial IGA: 3.6. Mean initial DLQI: 6. TPRP n = 34 (range: 2-9; average: 6.8 per patient). Mean IGA at 18 months: 3.25. Mean DLQI at 18 months: 1.25. All patients reporte...Continue Reading

References

Jun 29, 2011·Journal of the European Academy of Dermatology and Venereology : JEADV·E V J EdmondsC B Bunker
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Dec 15, 2012·Journal of Plastic, Reconstructive & Aesthetic Surgery : JPRAS·C E SommelingS Monstrey
Dec 18, 2016·Journal of the American Academy of Dermatology·Andrew T GoldsteinRichard Pfau
Jul 28, 2017·Journal of the European Academy of Dermatology and Venereology : JEADV·G KravvasC B Bunker
Jan 10, 2018·The British Journal of Dermatology·F M LewisL S Exton
Jul 28, 2018·Journal of the European Academy of Dermatology and Venereology : JEADV·M TedescoA Morrone
Sep 27, 2018·Journal of Lower Genital Tract Disease·Panteha Eshtiaghi, Leslie Ann Sadownik
Feb 23, 2019·Journal of Tissue Engineering and Regenerative Medicine·William H MerchánAna L Muñoz
Jun 18, 2019·Clinical and Experimental Dermatology·T N ShimC B Bunker
Dec 7, 2019·World Journal of Urology·Amanda S J Chung, Oscar A Suarez

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