Platelet-rich plasma for muscle injuries: A systematic review of the basic science literature

World Journal of Orthopedics
Kyle N KunzeBrian J Cole

Abstract

Platelet-rich plasma (PRP) is an increasingly used biologic adjunct for muscle injuries, as it is thought to expedite healing. Despite its widespread use, little is known regarding the mechanisms by which PRP produces its efficacious effects in some patients. To clarify the effects of PRP on muscular pathologies at the cellular and tissue levels by evaluating the basic science literature. A systematic review of PubMed/MEDLINE and EMBASE databases was performed using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines and checklist. Level III in vivo and in vitro studies examining PRP effects on muscles, myocytes and/or myoblasts were eligible for inclusion. Extracted data included PRP preparation methods and study results. Twenty-three studies were included (15 in vivo, 6 in vitro, 2 in vitro/in vivo). Only one reported a complete PRP cytology (platelets, and red and white blood cell counts). Five in vitro studies reported increased cellular proliferation, four reported increased gene expression, and three reported increased cellular differentiation. Five in vivo studies reported increased gene expression, three reported superior muscle regeneration, and seven reported improved histologica...Continue Reading

References

Mar 14, 2009·The American Journal of Sports Medicine·Jason W HammondRichard M Lovering
Apr 25, 2012·Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA·Tomokazu YoshiokaNaoyuki Ochiai
May 4, 2012·The Journal of Bone and Joint Surgery. American Volume·N Lindsay HarrisMark L Purnell
Jul 18, 2012·The American Journal of Sports Medicine·Augustus D MazzoccaKnut Beitzel
Jun 20, 2013·The Journal of Bone and Joint Surgery. American Volume·Satoshi TeradaJohnny Huard
Jul 23, 2013·Blood Transfusion = Trasfusione Del Sangue·Paolo BorrioneFabio Pigozzi
Jul 23, 2013·Journal of Tissue Engineering and Regenerative Medicine·Michael J McClureJeffery J Ericksen
Jul 25, 2014·The American Journal of Sports Medicine·Demetris DelosScott Alan Rodeo
Nov 5, 2015·Revista Brasileira De Ortopedia·Marcelo Luiz QuarteiroIzabelli Silveira
Nov 26, 2015·Muscles, Ligaments and Tendons Journal·Mandeep Singh DhillonAlka Bhatia
May 25, 2016·The American Journal of Sports Medicine·Priscila Martins Andrade DenapoliRene Jorge Abdalla
Jun 4, 2016·Platelets·Rodrigo Pereira MartinsGustavo Orione Puntel
Sep 22, 2016·Lasers in Medical Science·Guilherme Akio Tamura OzakiJosé Carlos Silva Camargo Filho
Sep 30, 2016·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Fumiaki TakaseMasahiro Kurosaka
Feb 25, 2017·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Wen-Chung TsaiJong-Hwei S Pang
Apr 30, 2017·The American Journal of Sports Medicine·Paola Contreras-MuñozMario Marotta
Jul 25, 2017·Brazilian Journal of Physical Therapy·Thiago Alves GarciaJosé Carlos Silva Camargo Filho

❮ Previous
Next ❯

Methods Mentioned

BETA
biopsies

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Arthroscopy : the Journal of Arthroscopic & Related Surgery : Official Publication of the Arthroscopy Association of North America and the International Arthroscopy Association
Eoghan T HurleyHannan Mullett
Arthroscopy : the Journal of Arthroscopic & Related Surgery : Official Publication of the Arthroscopy Association of North America and the International Arthroscopy Association
Michael P FiceJohn G Kennedy
© 2021 Meta ULC. All rights reserved