Platelet-rich plasma in fibrin matrix to augment rotator cuff repair: a prospective, single-blinded, randomized study with 2-year follow-up

Journal of Shoulder and Elbow Surgery
Michael R WalshMegan Reams

Abstract

Application of autologous platelet-rich plasma in fibrin matrix (PRPFM) improves tendon healing in patients undergoing arthroscopic rotator cuff repair. We performed a prospective, randomized, single-blinded study of 76 patients, with an α level of 5% and power of 80%. Seventy-six patients were divided into 2 randomized groups. The treatment group underwent arthroscopic rotator cuff repair with PRPFM. The control group did not receive the PRPFM treatment. Patients were evaluated preoperatively and at 6 months and 24 months postoperatively with validated clinical outcome scores, and dynamometer examination. A magnetic resonance imaging scan was performed at 6 months postoperatively. The 2 randomized groups were homogeneous. Western Ontario Rotator Cuff (WORC) scores were not statistically different at any time interval. The WORC scores changed from 1257 to 139 in the control group and from 1106 to 99 in the PRPFM group over the 24-month study period. On the Simple Shoulder Test, improvement over the study period was noted from 45% to 96% in the control group and from 49% to 96% in the PRPFM group. Strength of the supraspinatus at 24 months by dynamometer testing was 99.8% in the control group and 96.3% in the PRPFM group. Infras...Continue Reading

Citations

Oct 19, 2019·The Journal of Bone and Joint Surgery. American Volume·Robert Z Tashjian, Peter N Chalmers
Sep 24, 2020·International Journal of Environmental Research and Public Health·Vincenzo CandelaVincenzo Denaro
Dec 29, 2020·Arthroscopy : the Journal of Arthroscopic & Related Surgery : Official Publication of the Arthroscopy Association of North America and the International Arthroscopy Association·Gregorio Alejandro Villarreal-VillarrealCarlos Alberto Acosta-Olivo
Mar 2, 2021·The American Journal of Sports Medicine·Robert L ParisienDean Wang
Mar 22, 2021·Arthroscopy : the Journal of Arthroscopic & Related Surgery : Official Publication of the Arthroscopy Association of North America and the International Arthroscopy Association·James RyanCharles Gatt
May 31, 2021·Arthroscopy : the Journal of Arthroscopic & Related Surgery : Official Publication of the Arthroscopy Association of North America and the International Arthroscopy Association·Yinghao LiYan Xiong
Aug 28, 2021·Arthroscopy : the Journal of Arthroscopic & Related Surgery : Official Publication of the Arthroscopy Association of North America and the International Arthroscopy Association·Robin HoltedahlJens Ivar Brox
Sep 2, 2021·BMC Musculoskeletal Disorders·Umile Giuseppe LongoVincenzo Denaro
Dec 22, 2021·The Journal of the American Academy of Orthopaedic Surgeons·David KovacevicStavros Thomopoulos

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