Platelet-Rich Plasma Injection in Burn Scar Areas Alleviates Neuropathic Scar Pain

International Journal of Medical Sciences
Shu-Hung HuangHui-Min David Wang

Abstract

Objective: No effective treatments have yet been developed for burn-induced neuropathic pain. Platelet-rich plasma (PRP) has been reported to ameliorate various types of inflammation pain. However, the effect of PRP on burn-induced neuropathic pain is unclear. Methods: Burn-induced neuropathic pain Sprague-Dawley rat model was confirmed using a mechanical response test 4 weeks after the burn injuries were sustained, following which PRP was injected in the scar area. The rats were divided into four groups (n = 6) as following: Group A, Sham; Group B, Sham + PRP; Group C, Burn; and Group D, Burn + PRP. Four weeks after the PRP injection, the animals were subjected to behavior tests and then sacrificed; specimens were collected for inflammation tests, Masson's trichrome stain and chromosome 10 (PTEN) in the injured skin; and PTEN, phosphorylated mammalian target of rapamycin (p-mTOR), p38, nuclear factor κB (NFκB), chemokine (CC motif) ligand 2 (CCL2), and CCL2 cognate receptor (CCR2) in spinal cord dorsal horns through immunohistochemistry and immunofluorescence staining. Results: PRP significantly alleviated allodynia in burn-induced neuropathic pain 4 weeks after treatment, and PTEN expression in the skin and spinal cord were s...Continue Reading

Citations

Feb 23, 2019·Journal of Tissue Engineering and Regenerative Medicine·William H MerchánAna L Muñoz
Nov 5, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ying-Chen ChengHui-Min David Wang
Nov 17, 2020·Journal of Plastic Surgery and Hand Surgery·Christopher F BrewerBen H Miranda
May 19, 2021·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Ping-Ruey ChouSheng-Hua Wu
Jun 15, 2021·BioMed Research International·Xinheng LiuHongmian Li
Jul 22, 2021·European Journal of Pain : EJP·Yohann BohrenEric Salvat

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Methods Mentioned

BETA
enzyme-linked immunosorbent assay
ELISA

Software Mentioned

Image
Quantity One
Pro Plus
Statistical Package for the Socail Scinecnes ( SPSS

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