Platelet-Rich Plasma Releasate Promotes Regeneration and Decreases Inflammation and Apoptosis of Injured Skeletal Muscle

The American Journal of Sports Medicine
Wen-Chung TsaiJong-Hwei S Pang

Abstract

Platelet-rich plasma (PRP) contains various cytokines and growth factors that may be beneficial to the healing process of injured muscle. Based on the authors' previous study, PRP releasate can promote proliferation and migration of skeletal muscle cells in vitro, so animal studies are performed to support the use of PRP to treat muscle injury in vivo. To investigate the effect of PRP releasate on regeneration of injured muscle, as well as its effect on inflammatory reaction and cell apoptosis, in the early stages of the muscle-healing process. Controlled laboratory study. The gastrocnemius muscles of Sprague-Dawley rats were injured by partial transverse incision and then treated with PRP releasate. Hematoxylin and eosin stain was used to evaluate the healing process of injured muscle at 2, 5, and 10 days after injury. TUNEL assay was used to evaluate the cell apoptosis of injured muscle after PRP releasate treatment. Immunohistochemistry was used to stain the CD68-positive cells during the healing process. Muscle contractile properties, including fast-twitch and tetanic strength, were evaluated by electric stimulation. The results revealed that PRP releasate treatment could enhance the muscle-healing process and decrease CD68...Continue Reading

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References

Jul 1, 1994·The American Journal of Sports Medicine·W T ObremskyW E Garrett
Feb 1, 1994·The Journal of Clinical Investigation·J HuardJ P Tremblay
Mar 1, 1993·The American Journal of Sports Medicine·D C TaylorW E Garrett
Apr 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·B J PetrofH L Sweeney
Feb 8, 2000·Clinical Orthopaedics and Related Research·C KasemkijwattanaJ Huard
Mar 4, 2000·The Journal of Bone and Joint Surgery. British Volume·J MenetreyJ Huard
Jul 31, 2001·The American Journal of Sports Medicine·K FukushimaJ Huard
Oct 3, 2001·The Journal of Cell Biology·M WehlingJ G Tidball
Jan 30, 2002·Implant Dentistry·R E Marx
Sep 6, 2002·The American Journal of Pathology·Yong Li, Johnny Huard
Aug 16, 2003·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·William FosterJohnny Huard
Oct 29, 2004·Plastic and Reconstructive Surgery·Barry L EppleyJoel Higgins
Oct 29, 2004·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Candan EfeogluSelda Ertürk
Jan 8, 2005·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·James G Tidball
Apr 27, 2005·The American Journal of Sports Medicine·Tero A H JärvinenMarkku Järvinen
Dec 6, 2005·The Journal of Craniofacial Surgery·William S Pietrzak, Barry L Eppley
Mar 17, 2006·Trends in Biotechnology·Eduardo AnituaIsabel Andía
Sep 2, 2008·Journal of Cellular Biochemistry·D D W Cornelison
Dec 10, 2008·Clinics in Sports Medicine·Allan MishraAmy Vieira
Mar 14, 2009·The American Journal of Sports Medicine·Jason W HammondRichard M Lovering
Oct 31, 2009·The American Journal of Sports Medicine·Timothy E FosterScott A Rodeo
Apr 30, 2010·Molecular Biology of the Cell·Charlene Clow, Bernard J Jasmin
Jun 23, 2010·Journal of Cellular Physiology·Paola BendinelliMaria Alfonsina Desiderio
Sep 22, 2010·American Journal of Physical Medicine & Rehabilitation·Paolo BorrioneFabio Pigozzi
Nov 26, 2010·British Journal of Sports Medicine·Lars EngebretsenGeoffrey Verrall
Jul 18, 2012·The American Journal of Sports Medicine·Augustus D MazzoccaKnut Beitzel
Jul 25, 2014·The American Journal of Sports Medicine·Demetris DelosScott Alan Rodeo
Jul 31, 2014·The American Journal of Sports Medicine·Mohamad Shariff A HamidLeena Poh Chen Lee
Apr 18, 2016·Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA·Luciano Andrés RossiCristina María Elizondo
Feb 25, 2017·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Wen-Chung TsaiJong-Hwei S Pang
Aug 13, 2017·Arthroscopy : the Journal of Arthroscopic & Related Surgery : Official Publication of the Arthroscopy Association of North America and the International Arthroscopy Association·Ujash ShethJaskarndip Chahal

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Citations

Feb 16, 2019·International Journal of Molecular Sciences·Flaminia ChelliniChiara Sassoli
Oct 22, 2018·Current Reviews in Musculoskeletal Medicine·Kian SetayeshW Stephen Choate
Jan 16, 2021·Experimental Physiology·Joseph BarlowAntonios Matsakas
Nov 23, 2020·Military Medical Research·Peng-Cheng XuBiao Cheng
Feb 13, 2021·International Journal of Molecular Sciences·Diego DelgadoMikel Sánchez
May 8, 2021·Orthopaedic Journal of Sports Medicine·Tung-Yang YuWen-Chung Tsai
Jun 25, 2021·International Immunopharmacology·Sara Mohamed Naguib Abdel HafezHeba A Abdel-Hamid
Aug 6, 2021·The American Journal of Sports Medicine·Wen-Chung TsaiJong-Hwei S Pang
Aug 17, 2021·Journal of Back and Musculoskeletal Rehabilitation·Gökhan Tuna ÖztürkAlper Murat Ulašlı
Jul 27, 2021·Medicine and Science in Sports and Exercise·Lukas M TrunzJohannes B Roedl

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Methods Mentioned

BETA
force measurements

Software Mentioned

Pro Premier
Image
PowerLab

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