Mar 31, 2018

Platelet-rich plasma shows beneficial effects for patients with knee osteoarthritis by suppressing inflammatory factors

Experimental and Therapeutic Medicine
Guilin HuangXiujin Chen

Abstract

Knee osteoarthritis is a degenerative disease that may develop due ageing, obesity, strain, congenital abnormal joints, joint deformity or trauma. It is caused by many factors, such as degradation of articular cartilage injury, joint edge and subchondral bone hyperplasia of reactivity. Platelet-rich plasma (PRP) is an autologous blood sample that contains highly concentrated platelets and multiple cell growth factors. PRP promotes synovial cell proliferation and differentiation and may recover cartilage morphology. In the present study, the clinical efficacy of PRP was investigated in patients with knee osteoarthritis aged between 18 and 30 years in a phase-III clinical study. Following an 8-week baseline, patients with knee osteoarthritis were randomized into once-weekly, double-blind treatment with PRP (2-14 ml) or placebo groups. The results indicated that patients with osteoarthritis treated with PRP had modulated plasma concentrations of inflammatory factors and pro-angiogenic factors compared with the placebo group. Treatment responses were assessed by median percent reduction in inflammatory and pro-angiogenic factors and these improved with PRP treatment compared with the placebo. Clinical data indicated that PRP allevi...Continue Reading

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Mentioned in this Paper

Study
Clinical Study by Phase
Degenerative Polyarthritis
Articular System
Angiogenic Process
Science of Morphology
Structure of Articular Cartilage
Pulmonary Fibrosis
Proteinuria
Emergency Treatment

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