Platelet secretory products increase low density lipoprotein oxidation, enhance its uptake by macrophages, and reduce its fluidity

Arteriosclerosis : an Official Journal of the American Heart Association, Inc
M AviramJ G Brook

Abstract

Oxidized low density lipoprotein (Ox-LDL) is considered to be involved in the atherogenic process. Factors influencing the formation of Ox-LDL are thus of importance. Oxidation of LDL in a cell-free system in the presence of copper ions was significantly increased (up to 60%) by the presence of platelet-conditioned medium, (PCM) obtained from collagen-activated platelets for the duration of the oxidation period. The effect was time- and dose-dependent and was related to hydrogen peroxide and superoxide production, since PCM-induced enhanced LDL oxidation was inhibited by catalase and by superoxide dismutase, but not by protease treatments. PCM also reduced the fluidity of oxidized LDL by 45%. Upon incubation with a J-774 macrophage-like cell line, PCM-treated Ox-LDL enhanced cellular cholesteryl ester synthesis by 47% and lipoprotein degradation by 41%. Thus platelet secretory products appeared to enhance LDL oxidation through the involvement of oxidative agents. The resulting Ox-LDL demonstrated increased atherogenic properties.

References

Jul 1, 1979·Progress in Cardiovascular Diseases·A I Schafer, R I Handin
Nov 2, 1976·Biochemistry·S J Shattil, R A Cooper
Feb 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·W PalinskiJ L Witztum
Jan 1, 1989·Journal of Clinical Chemistry and Clinical Biochemistry. Zeitschrift Für Klinische Chemie Und Klinische Biochemie·M AviramG Brook
Apr 6, 1989·The New England Journal of Medicine·D SteinbergJ L Witztum
Apr 1, 1989·Atherosclerosis·N G ArdlieL A Simons
Aug 1, 1987·The Journal of Clinical Investigation·L K CurtissE F Plow
Jul 1, 1988·Seminars in Thrombosis and Hemostasis·J G Brook, M Aviram
Jul 1, 1987·Progress in Cardiovascular Diseases·M Aviram, J G Brook
Jan 1, 1988·The Journal of Clinical Investigation·M E Mendelsohn, J Loscalzo
Feb 20, 1986·The New England Journal of Medicine·R Ross
Jan 1, 1983·Annual Review of Biochemistry·M S Brown, J L Goldstein
Sep 1, 1981·The American Journal of Medicine·B B Weksler, R L Nachman

❮ Previous
Next ❯

Citations

Feb 1, 1991·Clinical Cardiology·C J SchwartzR M Nerem
Dec 1, 1993·Zeitschrift für Ernährungswissenschaft·H Gerster
Oct 7, 2000·Bulletin of Experimental Biology and Medicine·O A AzizovaY M Lopukhin
Jan 1, 1995·Molecular Aspects of Medicine·M J Halpern
Sep 1, 1991·Journal of Clinical Pathology·P GörögI B Kovacs
Feb 1, 1993·European Journal of Clinical Chemistry and Clinical Biochemistry : Journal of the Forum of European Clinical Chemistry Societies·A LavyM Aviram
Oct 1, 1995·European Journal of Clinical Chemistry and Clinical Biochemistry : Journal of the Forum of European Clinical Chemistry Societies·T HayekM Aviram
Oct 21, 2014·Journal of Obesity·Jaime GonzalezRodrigo Moore-Carrasco
Jan 11, 2001·Journal of Cardiovascular Pharmacology and Therapeutics·A Corsini
Apr 1, 1992·Arteriosclerosis and Thrombosis : a Journal of Vascular Biology·S KeidarM Aviram
Aug 11, 2000·Arteriosclerosis, Thrombosis, and Vascular Biology·I VolfE Koller
Apr 29, 1998·Arteriosclerosis, Thrombosis, and Vascular Biology·M KaplanM Aviram
Nov 2, 2011·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Denis BlacheLaurent Lagrost
Oct 1, 1991·European Journal of Clinical Chemistry and Clinical Biochemistry : Journal of the Forum of European Clinical Chemistry Societies·M AviramG J Brook
Jan 22, 2003·European Journal of Clinical Investigation·L PuccettiF Bruni
Aug 1, 1991·Metabolism: Clinical and Experimental·A LavyM Aviram
Sep 15, 1991·The American Journal of Cardiology·Y ChancerelleJ F Kergonou

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Hereditary Sensory Autonomic Neuropathy

Hereditary Sensory Autonomic Neuropathies are a group of inherited neurodegenerative disorders characterized clinically by loss of sensation and autonomic dysfunction. Here is the latest research on these neuropathies.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Landau-Kleffner Syndrome

Landau Kleffner syndrome (LKS), also called infantile acquired aphasia, acquired epileptic aphasia, or aphasia with convulsive disorder, is a rare childhood neurological syndrome characterized by the sudden or gradual development of aphasia (the inability to understand or express language) and an abnormal electroencephalogram. Discover the latest research on LKS here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Regulation of Vocal-Motor Plasticity

Dopaminergic projections to the basal ganglia and nucleus accumbens shape the learning and plasticity of motivated behaviors across species including the regulation of vocal-motor plasticity and performance in songbirds. Discover the latest research on the regulation of vocal-motor plasticity here.