PMID: 9657420Jul 10, 1998Paper

Platelet serotonergic functions and light therapy in seasonal affective disorder

Psychiatry Research
R Stain-MalmgrenA Aberg-Wistedt

Abstract

We investigated platelet 14C-serotonin uptake and platelet [3H]LSD and [3H]paroxetine binding in 11 patients with seasonal affective disorder (SAD). Patients were reinvestigated after light therapy, applied at 07.00-09.00 h for 10 consecutive days. The degree of depression was rated before and after light therapy using the Comprehensive Psychopathological Rating Scale (CPRS). Baseline data in patients were compared with data from a control group consisting of 11 age- and sex-matched healthy volunteers. Seven patients responded to light therapy with a > 50% reduction in CPRS scores. In non-responders, the reduction in CPRS was 24.7 +/- 5.5%. There was a significant inverse correlation (P = 0.014) between Km for platelet 14C-serotonin uptake and CPRS scores. Patients had significantly higher Bmax for platelet [3H]LSD binding (P = 0.04) and significantly lower Bmax for platelet [3H]paroxetine binding (P = 0.016). There was a strong, multiple correlation between Bmax for [3H]LSD, as the dependent variable, and Km, Vmax and Bmax for [3H]paroxetine binding in patients (P < 0.0001) but not in controls. Responders to light therapy had significantly higher Km (P = 0.023) and significantly lower Bmax for [3H]paroxetine binding (P = 0.028...Continue Reading

References

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Citations

Apr 21, 2001·Journal of Affective Disorders·A J Van der Does
Mar 10, 2000·Journal of Affective Disorders·S D Mendelson
Sep 21, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Matthäus WilleitErnst A Singer
Mar 10, 2001·International Clinical Psychopharmacology·R Stain-MalmgrenA Tham
Sep 3, 2005·Psychological Science·Matthew C KellerTor Wager
Feb 27, 2001·Journal of Affective Disorders·M FritzscheH Kick
Aug 31, 2010·Journal of Photochemistry and Photobiology. B, Biology·Mats B Humble
Aug 4, 2005·Neurochemical Research·Aroldo CupelloClaudio Albano

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