PMID: 8599403Apr 1, 1996Paper

Platelet serotonin 2A (5-HT2A) receptor characteristics and parenting factors for boys at risk for delinquency: a preliminary report

The American Journal of Psychiatry
D S PineB Parsons

Abstract

This study examined the cross-sectional association between platelet membrane serotonin 2A (5-HT2A) receptor variables in children and characteristics of their parents that place these children at risk for antisocial behavior. As part of a larger prospective study investigating predictors of antisocial behavior, 38 younger brothers of convicted delinquents provided platelet samples; samples from 34 boys (mean age=8.3 years) were usable. The authors determined the density (Bmax) and affinity (Kd) of platelet membrane 5-HT2A receptors by using [3H]lysergic acid diethylamide. They also measured parental characteristics related to serotonergic dysfunction in prior studies, the quality of parent-child interactions, and psychiatric profiles of the boys who provided platelets. Bmax was significantly lower in boys whose parents had histories of substance abuse or incarceration. Bmax was also inversely related to harsh parenting; boys raised in environments characterized by frequent parental physical punishment and anger had a significantly lower Bmax. Bmax was not related to boys' disruptive behavior. In boys at risk for antisocial behavior, the density of 5-HT2A receptors on platelets is inversely related to parental factors known to ...Continue Reading

Citations

Jun 5, 1998·The Journal of Nervous and Mental Disease·C R PfefferT Kakuma
Nov 18, 2018·Acta Psychiatrica Scandinavica·Kevin C RunionsFlorian D Zepf
Jun 20, 2002·Acta Psychiatrica Scandinavica. Supplementum·S LangP-O Alm
Apr 15, 2006·Development and Psychopathology·Jackie K GollanEmil F Coccaro
Apr 6, 2004·Journal of Personality Disorders·Paul J Markovitz
Dec 21, 2000·Current Psychiatry Reports·L M Gatzke, A Raine
May 12, 2019·Developmental Psychobiology·Andrew R FoxAmy H Mezulis
Sep 14, 2002·Zeitschrift für Kinder- und Jugendpsychiatrie und Psychotherapie·U J GerhardB Blanz

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