Platelet serotonin in combat related posttraumatic stress disorder with psychotic symptoms

Journal of Affective Disorders
Nela PivacDorotea Mück-Seler

Abstract

Combat-related posttraumatic stress disorder (PTSD) is severe form of PTSD, frequently associated with psychotic symptoms. Platelet serotonin (5-hydroxytryptamine, 5-HT) was used as a peripheral 5-HT marker to identify particular symptoms in PTSD. Platelet 5-HT was determined fluorimetrically in 67 war veterans with combat related PTSD, 36 combat exposed veterans who did not develop PTSD, 35 veterans with PTSD complicated with psychotic features. PTSD diagnosis of current and chronic PTSD, and clinical symptoms of PTSD and psychoses were assessed according to DSM-IV criteria, using the Clinician Administrated PTSD Scale, and Positive and Negative Syndrome Scale (PANSS). Platelet 5-HT concentration was significantly higher in veterans with psychotic PTSD than in veterans with non-psychotic PTSD, veterans without PTSD, or in control subjects. Platelet 5-HT was significantly positively correlated with the positive symptoms in PANSS subscale, and with the symptoms of delusions within PANSS positive subscale. The results were obtained on peripheral 5-HT marker, i.e. platelet 5-HT concentration. Since the delusions are the core psychotic symptoms occurring in our psychotic PTSD patients, the result of the increased platelet 5-HT conc...Continue Reading

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Citations

Jul 16, 2009·Progress in Neuro-psychopharmacology & Biological Psychiatry·Dorotea Muck-SelerVera Folnegovic-Smalc
May 9, 2009·Medical Hypotheses·Lei ZhangRobert Ursano
Dec 7, 2007·Progress in Neuro-psychopharmacology & Biological Psychiatry·Zrnka KovacicAndrea Borovecki
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Jul 6, 2006·Journal of Affective Disorders·Marina SagudDorotea Muck-Seler
Jul 7, 2011·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Nela PivacDorotea Muck-Seler
May 2, 2006·Journal of Affective Disorders·Nela PivacDorotea Muck-Seler
Nov 1, 2013·World Journal of Psychiatry·Pia Koudouovoh-Tripp, Barbara Sperner-Unterweger
Sep 29, 2015·Experimental Neurobiology·Hee Jin KangIn Kyoon Lyoo
May 20, 2021·Stress : the International Journal on the Biology of Stress·Tajana Ljubin-GolubNela Pivac

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