Platelet serotonin transporter in children and adolescents with obsessive-compulsive disorder or Tourette's syndrome

Journal of the American Academy of Child and Adolescent Psychiatry
F R SalleeL Nesbitt

Abstract

Previous studies of serotonin transporter protein (5HTPR) indexed in platelets by 3H-imipramine demonstrate reduction in children with comorbid obsessive-compulsive disorder (OCD) and Tourette's syndrome (TS). To use the 5HTPR selective ligand 3H-paroxetine and homogeneous diagnostic groups to reevaluate these findings. Platelet Kinetic binding parameters were evaluated using standard techniques from medication-free child and adolescent patients with OCD (n = 18), with TS (n = 10), and normal controls (n = 19). Baseline binding capacity (Bmax) was significantly reduced in patients with OCD (1,342 +/- 952 fmol/mg; protein p < .01) compared with normal controls (2,486 +/- 1309 fmol/mg) and TS patients (2,420 +/- 1,069 fmol/mg; p < .05). Among OCD patients who were subsequently treated on an open-label basis with selective serotonin reuptake inhibitor (SSRI), Bmax values at baseline differentiated between responders (1,718 +/- 1,041 fmol/mg) and nonresponders (802 +/- 713 fmol/mg protein; p < .05). Response to SSRI was greatest in patients with a positive family history of OCD. Among responders (n = 10), baseline Yale-Brown Obsessive Compulsive Scale and Bmax were positively correlated (r = .76, p = .01), as was Clinical Global Im...Continue Reading

References

Jul 1, 1979·Annals of Neurology·I J ButlerH S Singer
Mar 1, 1992·Journal of the American Academy of Child and Adolescent Psychiatry·P J AmbrosiniH Y Meltzer
Nov 1, 1992·Journal of the American Academy of Child and Adolescent Psychiatry·M A RiddleD J Cohen
Sep 1, 1992·Archives of General Psychiatry·T R Insel
May 1, 1992·Journal of the American Academy of Child and Adolescent Psychiatry·J T WalkupH S Singer
Sep 1, 1991·Biological Psychiatry·S W KimJ M Davis
Jul 1, 1991·Acta Psychiatrica Scandinavica·B VitielloE Friedman
Mar 1, 1991·Journal of the American Academy of Child and Adolescent Psychiatry·G L HannaD P Cantwell
Nov 1, 1990·Neurobiology of Aging·A Andersson, J Marcusson
Oct 1, 1990·Acta Psychiatrica Scandinavica·E T Mellerup, P Plenge
Jan 1, 1990·Journal of the American Academy of Child and Adolescent Psychiatry·M A RiddleJ L Woolston
Nov 1, 1985·Biological Psychiatry·T R InselD L Murphy
Jul 1, 1980·Annals of Neurology·W E SeifertI J Butler
Nov 1, 1980·Archives of General Psychiatry·P ThorénL Träskman
Sep 1, 1980·Analytical Biochemistry·P J Munson, D Rodbard
Mar 1, 1984·Journal of the American Academy of Child Psychiatry·D F HarcherikD J Cohen
Mar 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·S RamamoorthyR D Blakely
Feb 1, 1995·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·J F LeckmanD L Pauls
Jan 1, 1995·The American Journal of Psychiatry·D L PaulsJ F Leckman
Jan 1, 1995·Journal of the American Academy of Child and Adolescent Psychiatry·G L HannaJ K Coates
Jan 1, 1995·Journal of the American Academy of Child and Adolescent Psychiatry·D A GellerT E Wilens
Apr 1, 1994·The British Journal of Psychiatry : the Journal of Mental Science·J C HolzerL H Price
Mar 1, 1994·Journal of the American Academy of Child and Adolescent Psychiatry·A ApterM A Riddle
Oct 1, 1993·Journal of Clinical Psychopharmacology·C J McDougleL H Price
Jan 1, 1993·The American Journal of Psychiatry·M S GeorgeM M Robertson
Jun 1, 1993·Archives of General Psychiatry·H L LeonardJ L Rapoport

❮ Previous
Next ❯

Citations

Oct 31, 2002·Human Psychopharmacology·Floyd R SalleeLauren Sine
Mar 9, 2000·Psychiatry Research·D MarazzitiG B Cassano
Aug 17, 2002·Psychoneuroendocrinology·Donatella MarazzitiGiovanni B Cassano
Jul 20, 2002·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Michal ZuckerMoshe Rehavi
May 12, 2005·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Richard DelormeMarion Leboyer
Jul 17, 1998·Journal of the American Academy of Child and Adolescent Psychiatry·F R SalleeL Nesbitt
Jan 8, 2004·Journal of Clinical Psychopharmacology·Richard DelormeMarion Leboyer
Apr 14, 2007·Acta Psychiatrica Scandinavica·S G HasselbalchT G Bolwig
Jul 16, 2016·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Borwin BandelowPeter Riederer
Jan 11, 2008·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Michael H BlochJames F Leckman
Apr 29, 1998·Current Opinion in Neurology·C Gillberg
Jan 17, 2004·Journal of the American Academy of Child and Adolescent Psychiatry·Donald L GilbertFloyd R Sallee

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anxiety Disorders

Discover the latest research on anxiety disorders including agoraphobia, panic disorder, obsessive-compulsive disorder, and post-traumatic stress disorder here.