Platelet Storage Lesions: What More Do We Know Now?

Transfusion Medicine Reviews
Monica Suet Ying NgJohn Francis Fraser

Abstract

Platelet concentrate (PC) transfusions are a lifesaving adjunct to control and prevent bleeding in cancer, hematologic, surgical, and trauma patients. Platelet concentrate availability and safety are limited by the development of platelet storage lesions (PSLs) and risk of bacterial contamination. Platelet storage lesions are a series of biochemical, structural, and functional changes that occur from blood collection to transfusion. Understanding of PSLs is key for devising interventions that prolong PC shelf life to improve PC access and wastage. This article will review advancements in clinical and mechanistic PSL research. In brief, exposure to artificial surfaces and high centrifugation forces during PC preparation initiate PSLs by causing platelet activation, fragmentation, and biochemical release. During room temperature storage, enhanced glycolysis and reduced mitochondrial function lead to glucose depletion, lactate accumulation, and product acidification. Impaired adenosine triphosphate generation reduces platelet capacity to perform energetically demanding processes such as hypotonic stress responses and activation/aggregation. Storage-induced alterations in platelet surface proteins such as thrombin receptors and gly...Continue Reading

Citations

Jun 18, 2019·Journal of Thrombosis and Haemostasis : JTH·Catherine AngénieuxBlandine Maître
Sep 10, 2020·Anesthesiology·Geir StrandenesTorunn Oveland Apelseth
Jul 29, 2018·European Journal of Haematology·Catherine M StefaniukRobert W Maitta
Jul 19, 2019·Frontiers in Immunology·Fabrice CognasseHind Hamzeh-Cognasse
Oct 4, 2018·Current Opinion in Hematology·Shailaja HegdeJose A Cancelas
Jul 31, 2020·Academic Pathology·Aaron D Shmookler, Melina B Flanagan
Nov 13, 2020·Arteriosclerosis, Thrombosis, and Vascular Biology·Binggang XiangZhenyu Li
Dec 17, 2020·Vox Sanguinis·Ben WoodLacey Johnson
Jan 30, 2021·Cell Death & Disease·Diane MoujalledEmma C Josefsson
Mar 12, 2021·Transfusion·Teresa Jimenez-MarcoEnrique Girona-Llobera
Mar 13, 2021·Hämostaseologie·Fabrice CognassePeter Larsen
Dec 3, 2020·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·Shashank OjhaMinal Poojary
Jan 29, 2020·Platelets·Paul VulliamyMatthew D Neal
May 6, 2021·International Journal of Molecular Sciences·Olga ShevchukAlbert Sickmann
May 25, 2021·Frontiers in Veterinary Science·Thomas H EdwardsAndrew P Cap
Aug 24, 2021·Platelets·Teresa Jimenez-MarcoJosé Rivera
Jul 8, 2021·Current Opinion in Hematology·Alice Tang, Avital Mendelson
Jun 14, 2019·Transfusion Medicine and Hemotherapy : Offizielles Organ Der Deutschen Gesellschaft Fur̈ Transfusionsmedizin Und Immunham̈atologie·Tanja VollmerJens Dreier
May 13, 2021·Transfusion Medicine and Hemotherapy : Offizielles Organ Der Deutschen Gesellschaft Fur̈ Transfusionsmedizin Und Immunham̈atologie·Xiaofei LiDeqing Wang
Jan 7, 2022·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Marianne E NellisUNKNOWN Pediatric Critical Care Transfusion and Anemia EXpertise Initiative–Control/Avoidance of Bleeding (TAXI-CAB), in collaborati

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