Platelet Surface CD62p and Serum Vitamin D Levels are Associated with Clopidogrel Resistance in Chinese Patients with Ischemic Stroke

Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association
Bi-Chao LuZhi-Zhong Liu

Abstract

To explore the association of platelet activation markers, vitamin D, and antiplatelet drugs resistance in ischemic stroke patients. A total of 230 patients with ischemic stroke were enrolled in this study. Platelet aggregation, platelet activation marker (CD62p), and vitamin D were measured after 7-14 days of dual antiplatelet treatment (aspirin + clopidogrel). All individuals were divided into a drug resistance group and a drug sensitive group according to the platelet maximum aggregation rate induced by antagonist adenosine diphosphate or arachidonic acid. In this study, the prevalence of aspirin resistance was low (1.2%), while the prevalence of clopidogrel resistance (CR) was 24.8%, so we focused on CR. The percentage of CD62p on activated platelet [(25.74 ± 4.61) versus (12.41 ± 3.93), P < .001] and the prevalence of hypertension [93.0% (53) versus 79.8% (138), P = .021] in CR group were significantly higher than those in clopidogrel sensitive (CS) group, while the vitamin D concentration [(8.96 ± 4.41) versus (13.9 ± 4.84) ng/mL, P = .003] in CR group was significantly lower compared with the CS group. No significant difference was found in soluble P-selectin between these 2 groups [(56.2 ± 16.13) versus (54.2 ± 14.87) n...Continue Reading

Citations

Apr 13, 2019·Current Neurovascular Research·Antonio SiniscalchiLuca Gallelli
May 18, 2020·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Vafa AlakbarzadeAnthony C Pereira

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