Platelet-surface glycoproteins in healthy and preeclamptic mothers and their newborn infants

Pediatric Research
T KühneJ Freedman

Abstract

Preeclampsia, a common complication of pregnancy, contributes significantly to maternal and fetal morbidity and mortality. It may lead to both quantitative and qualitative defects of maternal and neonatal platelets. In this prospective study, flow cytometry has been used to study expression of platelet-surface glycoproteins (GPs) on maternal and neonatal platelets of both healthy and preeclamptic subjects. We studied 15 preeclamptic women, 20-44 y of age, and their newborns (median gestational age, 32 wk; range, 26-38) and seven healthy women (aged 26-41 y) and their healthy newborns (median gestational age, 38 wk; range, 38-42). Compared with their healthy and preeclamptic mothers, resting platelets from neonates expressed significantly less CD41 and CD9. Thrombin activation resulted in significant increases in platelet-surface expression of CD62P, CD63, CD41, CD9, and CD36 in neonates and their healthy mothers. Compared with neonates of healthy mothers, platelets from neonates of preeclamptic mothers expressed lower levels of CD62P, CD63, CD9, and CD36 on activated platelets. These findings suggest that preeclampsia influences the expression of platelet-surface GPs on neonatal and maternal platelets, which may affect platelet...Continue Reading

References

Jul 26, 1989·Journal of Immunological Methods·V L LimM R Garovoy
Jul 1, 1982·Seminars in Thrombosis and Hemostasis·B GibsonJ G Kelton
Jul 1, 1994·Arteriosclerosis and Thrombosis : a Journal of Vascular Biology·A D MichelsonM R Barnard

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Citations

Jun 10, 2014·Clinica Chimica Acta; International Journal of Clinical Chemistry·Letícia Gonçalves FreitasLuci Maria SantAna Dusse
Aug 8, 2015·Clinics in Perinatology·Antonio Del VecchioCostantino Romagnoli
Jul 14, 2005·Platelets·A G SitaruR Grossmann
Feb 24, 2001·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·B KleinW Rath
Apr 3, 2016·Reproductive Sciences·Ivo BrosensGiuseppe Benagiano
Apr 16, 2019·Platelets·Carina JakobsenAnne-Mette Hvas
Jul 1, 2020·Pediatric Research·Akhil Maheshwari
Aug 22, 2017·Journal of Proteome Research·Eva StokhuijzenAlexander Benjamin Meijer

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