Platelet thromboxane synthesizing activity in non-insulin-dependent diabetes: correlation with diabetic retinopathy and diabetic treatment

Prostaglandins, Leukotrienes, and Medicine
R TakahashiH Orimo

Abstract

Since elevated thromboxane A2 synthesis could be expected to lead to microvascular injury in diabetic patients, it is important to determine the relationship between thromboxane A2 synthesis and diabetic microvascular complications. In the present study, the activity of thromboxane A2 synthesis in platelets was assessed in 57 Type 2 (non-insulin-dependent) diabetic patients by measuring the conversion of exogenously added 14C-arachidonic acid into 14C-thromboxane B2. The activity of thromboxane synthesis was significantly higher in diabetic patients than in 16 age-matched control subjects (2.61 +/- 0.07 vs 1.95 +/- 0.12 microgram . 10(9) platelets-1 . 3 min-1, respectively, p less than 0.001). When the diabetic patients were divided into three groups (nil, background, and proliferative retinopathy) on the basis of severity of diabetic retinopathy, there was a trend to increased thromboxane synthesizing activity as diabetic retinopathy develops. However, no statistically significant changes were demonstrated among these three groups. In the diabetic patients, a positive correlation was found between thromboxane synthesizing activities and glycosylated hemoglobin values (biochemical indicator of long-term glycemic control), but n...Continue Reading

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Citations

Feb 1, 1993·Pharmacology & Therapeutics·W G Mayhan
May 1, 1983·Prostaglandins, Leukotrienes, and Medicine·I MoritaS Murota
Dec 1, 1986·Prostaglandins, Leukotrienes, and Medicine·R TakahashiH Ito
Aug 26, 1999·Diabetes Research and Clinical Practice·W G MayhanG M Sharpe
Dec 18, 2003·The American Journal of Medicine·Paresh DandonaAjay Chaudhuri
Aug 1, 1995·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Y OnoT Koike
Apr 1, 1989·International Journal of Dermatology·M C HengM K Heng
Aug 17, 2004·The Medical Clinics of North America·Paresh DandonaAhmad Aljada
Mar 1, 1989·Prostaglandins, Leukotrienes, and Essential Fatty Acids·T Hendra, D J Betteridge
Jul 21, 2011·Ocular Immunology and Inflammation·Justus G GarwegJose G Montoya
Mar 1, 2011·European Journal of Microbiology & Immunology·L M Randall, C A Hunter
Dec 1, 2001·Prostaglandins, Leukotrienes, and Essential Fatty Acids·M Konieczkowski, V A Skrinska

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