Platelet Transfusion: And Update on Challenges and Outcomes

Journal of Blood Medicine
Pilar Solves Alcaina

Abstract

Platelet transfusion is a common practice in onco-hematologic patients for preventing or treating hemorrhages. Platelet concentrates can be transfused with therapeutic or prophylactic purposes. With the aim to help clinicians to take the decisions on platelet transfusion, some guidelines have been developed based on the current scientific evidence. However, there are some controversial issues and available scientific evidence is not enough to solve them. There is little information about what is the best platelet product to be transfused: random platelets or single donor apheresis platelets, and plasma-suspended or additive solution suspended platelets. Platelets are often transfused without respecting the ABO compatibility, but influence of this practice on platelet transfusion outcome is not well established. In the prophylactic platelet transfusion set there are some questions unsolved as the platelet threshold to transfuse prior to specific procedures or surgery, and even if platelet transfusion is necessary for some specific procedures as autologous hematopoietic stem cell transplantation. A challenging complication raised from multiple platelet transfusions is the platelet transfusion refractoriness. The study and managem...Continue Reading

Citations

Nov 21, 2020·Journal of Thrombosis and Haemostasis : JTH·Yukako Ono-UrugaYumiko Matsubara
Dec 8, 2020·Frontiers in Pediatrics·Stacie KahnOliver Karam
Jul 8, 2020·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·Olivier Garraud
Aug 20, 2021·Transfusion clinique et biologique : journal de la Société française de transfusion sanguine·M LikerB G Ćepulić
Aug 31, 2021·Platelets·Norman F LucAnirban Sen Gupta

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biopsy

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