Platelet volume heterogeneity in acute thrombocytopenia

Clinical Physics and Physiological Measurement : an Official Journal of the Hospital Physicists' Association, Deutsche Gesellschaft Für Medizinische Physik and the European Federation of Organisations for Medical Physics
E A TrowbridgeJ F Martin

Abstract

Platelet volume and count were measured by aperture impedance techniques in rats during acute thrombocytopenia 2, 6, 12 and 24 h and 3, 6, 9 and 11 days after a single injection of anti-platelet serum (APS). Platelet volume heterogeneity was quantified by four statistical parameters: the measure of central tendency, dispersion, asymmetry and convexity. None of the volume distributions, including the controls, was log Gaussian. Mean platelet volume increased for the first 6 h post APS and then started to decrease although the platelet count had not started to rise. There was an initial increase, followed by a smooth decrease to control values, in the coefficient of variation (suggesting an initial increased dispersion about the mean platelet volume) with concomitant decreases in asymmetry and convexity. In contrast the age of the platelets immediately after the APS injection must have a decreased dispersion about the mean age compared with control values. These facts are used to show that young platelets are not synonymous with large platelets even under the stress of acute thrombocytopenia and support the concept that thrombopoiesis is the dominant factor in determining platelet volume heterogeneity.

References

Aug 1, 1985·Clinical Physics and Physiological Measurement : an Official Journal of the Hospital Physicists' Association, Deutsche Gesellschaft Für Medizinische Physik and the European Federation of Organisations for Medical Physics·E A TrowbridgeC Pickering
Dec 1, 1965·American Journal of Clinical Pathology·B S BullG Brecher
Sep 1, 1983·American Journal of Clinical Pathology·C B ThompsonC R Valeri
Aug 1, 1984·Clinical Physics and Physiological Measurement : an Official Journal of the Hospital Physicists' Association, Deutsche Gesellschaft Für Medizinische Physik and the European Federation of Organisations for Medical Physics·E A TrowbridgeB Woodcock
Aug 1, 1984·British Heart Journal·D Oakley
Jul 1, 1983·British Journal of Haematology·J F MartinD G Penington
Nov 15, 1982·Thrombosis Research·J F MartinD N Slater
Mar 1, 1964·Proceedings of the Society for Experimental Biology and Medicine·T P MCDONALDD G GOSSLEE

❮ Previous
Next ❯

Citations

Jul 1, 1990·International Journal of Cell Cloning·A M Gladwin, J F Martin
Sep 23, 2009·International Journal of Clinical Practice·L VizioliA Muscari
Feb 12, 2014·BioMed Research International·Lisa H MasonDong Y Han
Feb 1, 1994·European Journal of Clinical Investigation·A S Brown, J F Martin
Oct 8, 1999·Vascular Medicine·N M SmithP M Bath
Jan 1, 1991·Platelets·S D Kristensen, J F Martin

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.