Platelet von Willebrand factor: sweet resistance.

Blood
P J Lenting, C V Denis

Abstract

In this issue of Blood, McGrath et al show that the terminal glycan structures of platelet von Willebrand factor (VWF) are markedly different compared with such structures present on plasma VWF.1 Unexpectedly, these differences endow platelet VWF with a specific resistance against proteolysis by the VWF-cleaving protease ADAMTS13, thereby potentially increasing the hemostatic potential of platelet VWF during the formation of platelet-rich thrombi.

References

Nov 1, 1994·British Journal of Haematology·S B WilliamsH R Gralnick
Jul 23, 2003·Journal of Thrombosis and Haemostasis : JTH·D J Bowen
Jan 14, 2010·British Journal of Haematology·Rachel T McGrathJames S O'Donnell
Jul 16, 2010·Haemophilia : the Official Journal of the World Federation of Hemophilia·P J LentingC V Denis
Feb 22, 2012·Biochimica Et Biophysica Acta·Thierry Hennet
May 31, 2012·Journal of Thrombosis and Haemostasis : JTH·S KanajiR R Montgomery

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Citations

May 23, 2018·Cardiovascular Engineering and Technology·Jevgenia Zilberman-RudenkoMartin A Schreiber
May 4, 2021·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Nonkululeko Hellen NaviseAletta E Schutte

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