Platelets amplify inflammation in arthritis via collagen-dependent microparticle production.

Science
Eric BoilardDavid M Lee

Abstract

In addition to their pivotal role in thrombosis and wound repair, platelets participate in inflammatory responses. We investigated the role of platelets in the autoimmune disease rheumatoid arthritis. We identified platelet microparticles--submicrometer vesicles elaborated by activated platelets--in joint fluid from patients with rheumatoid arthritis and other forms of inflammatory arthritis, but not in joint fluid from patients with osteoarthritis. Platelet microparticles were proinflammatory, eliciting cytokine responses from synovial fibroblasts via interleukin-1. Consistent with these findings, depletion of platelets attenuated murine inflammatory arthritis. Using both pharmacologic and genetic approaches, we identified the collagen receptor glycoprotein VI as a key trigger for platelet microparticle generation in arthritis pathophysiology. Thus, these findings demonstrate a previously unappreciated role for platelets and their activation-induced microparticles in inflammatory joint diseases.

References

Nov 1, 1978·Arthritis and Rheumatism·M H GinsbergJ L Skosey
May 1, 1967·British Journal of Haematology·P Wolf
Oct 1, 1983·Annals of the Rheumatic Diseases·M FarrJ Stuart
Feb 5, 1998·British Journal of Haematology·P A ValantY S Ahn
May 9, 2000·Lancet·J N George
Aug 8, 2001·The Journal of Cell Biology·S LindemannA S Weyrich
Sep 25, 2001·Lancet·D M Lee, M E Weinblatt
Jul 13, 2002·Arthritis and Rheumatism·E A J Knijff-DutmerM A F J van de Laar
Mar 22, 2003·Blood·Bernhard Nieswandt, Steve P Watson
Aug 9, 2003·Springer Seminars in Immunopathology·Diego Kyburz, Maripat Corr
Sep 24, 2004·Thrombosis Research·Masaaki Moroi, Stephanie M Jung
Nov 1, 2005·Nature Medicine·Matteo IannaconeLuca G Guidotti
Jan 31, 2006·Nature Immunology·Bryce A BinstadtChristophe Benoist
Feb 1, 1996·Clinical Molecular Pathology·K B PastakiaL Harvath
Jan 12, 2007·Cytometry. Part a : the Journal of the International Society for Analytical Cytology·Sílvia Perez-PujolNigel S Key
Jan 27, 2007·Science·David M LeeMichael B Brenner
Dec 14, 2007·The New England Journal of Medicine·Giovanni Davì, Carlo Patrono
Jan 1, 2008·Arthritis and Rheumatism·Charles G HelmickUNKNOWN National Arthritis Data Workgroup
Dec 26, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Kichul ShinDavid M Lee
Jan 23, 2009·The Cochrane Database of Systematic Reviews·Marty Mertens, Jasvinder A Singh

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Citations

Sep 4, 2012·Archivum Immunologiae Et Therapiae Experimentalis·Hsuan-Shun Huang, Hsin-Hou Chang
May 12, 2011·Cellular and Molecular Life Sciences : CMLS·Bence GyörgyEdit I Buzás
Jul 14, 2011·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Braedon McDonald, Paul Kubes
Aug 26, 2011·Seminars in Immunopathology·Olivier MorelFlorence Toti
Aug 6, 2011·Seminars in Immunopathology·Adriana Vieira-de-AbreuGuy A Zimmerman
Jun 22, 2011·Basic Research in Cardiology·Silvia Montoro-GarcíaGregory Y H Lip
Jul 28, 2011·Purinergic Signalling·Béatrice Hechler, Christian Gachet
Jun 19, 2013·Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban·Jia-Yan LingRui Zhu
Jul 28, 2010·Journal of Cardiovascular Translational Research·Christopher OmbrelloCraig N Morrell
Dec 20, 2012·Nature Communications·Ke TangBo Huang
Dec 25, 2012·Nature Genetics·Gosia TrynkaSoumya Raychaudhuri
Jan 5, 2011·Nature Reviews. Endocrinology·Larry J SuvaRobert J Griffin
Mar 26, 2011·Nature Reviews. Immunology·John W SempleJohn Freedman
Feb 26, 2013·Nature Reviews. Immunology·Elzbieta Kolaczkowska, Paul Kubes
Jul 3, 2010·Nature Reviews. Rheumatology·Jörg H W Distler, Oliver Distler
Aug 8, 2012·Nature Reviews. Rheumatology·Eric BoilardPeter A Nigrovic
Nov 14, 2012·Nature Reviews. Rheumatology·Berthold Hoppe, Thomas Dörner
Dec 7, 2011·Proceedings of the National Academy of Sciences of the United States of America·Yaël Berda-HaddadGilles Kaplanski
May 11, 2013·Molecular & Cellular Proteomics : MCP·Jesmond DalliMauro Perretti
Dec 21, 2012·Tissue Engineering. Part B, Reviews·Matthew B Fisher, Robert L Mauck
Jan 24, 2012·Cardiovascular Research·Leo TimmersDominique P V de Kleijn
Jun 19, 2013·Cardiovascular Research·Maarten Hulsmans, Paul Holvoet
Dec 12, 2012·The Journal of Infectious Diseases·Cornelia SpethGünter Rambach
Mar 10, 2012·Rheumatology·David S PisetskyTony C Ning
Apr 30, 2013·JAAPA : Official Journal of the American Academy of Physician Assistants·Thomas Moreau, UNKNOWN CHAC, Clinical and Health Affairs Commission of the AAPA
Mar 24, 2011·Current Opinion in Rheumatology·Faye A H Cooles, John D Isaacs
Jul 6, 2010·Current Opinion in Hematology·Mark R LooneyMichael A Matthay
Aug 27, 2010·Current Opinion in Hematology·Joseph E ItalianoRobert Flaumenhaft
Jul 11, 2013·Current Opinion in Hematology·Jerry WareReshma Khetpal
Dec 16, 2010·Current Opinion in Organ Transplantation·William M BaldwinCraig N Morrell
Feb 28, 2013·International Journal of Rheumatic Diseases·Kendall P CrookstonCarlos A Roldan
Oct 26, 2012·The Journal of Pharmacology and Experimental Therapeutics·Elisabetta LiveraniSatya P Kunapuli
Jan 30, 2010·Science·Guy A Zimmerman, Andrew S Weyrich
May 8, 2013·Molecular and Cellular Biology·Rie FujitaHozumi Motohashi
Jan 1, 2010·Advances in Virology·Sansanee NoisakranGuey Chuen Perng
Jan 26, 2012·Thrombosis and Haemostasis·M Al-TamimiR K Andrews
Apr 12, 2011·Thrombosis and Haemostasis·Alan T Nurden
Nov 13, 2010·Arteriosclerosis, Thrombosis, and Vascular Biology·Licia Totani, Virgilio Evangelista

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