Platelets and Antiplatelet Therapy in Patients with Coronary Artery Disease and Diabetes

Seminars in Thrombosis and Hemostasis
Søs Neergaard-PetersenErik L Grove

Abstract

Patients with diabetes mellitus are at increased risk of cardiovascular events. Despite advances in medical and interventional therapy, cardiovascular morbidity and mortality remains high in patients with diabetes. Although accelerated atherosclerosis has long been recognized as an underlying cause, recent studies suggest that changes in platelets and coagulation also play important roles. Patients with diabetes exhibit a prothrombotic milieu with hyperreactive platelets and coagulation abnormalities. Thus, prevention of cardiovascular events in patients with coronary artery disease (CAD) and diabetes involves a multifactorial approach including treatment of risk factors such as dyslipidemia, obesity, hypertension, hyperglycemia, and hypercoagulation. An impaired response to antiplatelet therapy has been consistently reported and optimization of this therapy seems appropriate to reduce the risk of cardiovascular events in these patients. In this review, platelet abnormalities are summarized together with an update of benefits and limitations of antiplatelet therapy in patients with CAD and diabetes.

Citations

Jul 8, 2017·Expert Opinion on Pharmacotherapy·Niki KatsikiDimitri P Mikhailidis
May 4, 2018·The Journal of Endocrinology·Prabhakara R NagareddyAndrew J Murphy
Apr 22, 2019·Diabetic Medicine : a Journal of the British Diabetic Association·L VernstrømK L Funck
Jun 2, 2017·Cardiovascular Diabetology·Isabella RussoPasquale Pagliaro
May 16, 2017·The Journal of Clinical Investigation·Michael J KraakmanAndrew J Murphy
Feb 2, 2021·Seminars in Thrombosis and Hemostasis·Joachim KvernbergAnne-Mette Hvas
Jan 15, 2021·Arteriosclerosis, Thrombosis, and Vascular Biology·Man K S LeeAndrew J Murphy
Apr 23, 2021·Circulation·Tiffany M Powell-WileyUNKNOWN American Heart Association Council on Lifestyle and Cardiometabolic Health; Council on Cardiovascular and Stroke Nursing; Co
Nov 28, 2017·Thrombosis Research·Liv VernstrømPer Løgstrup Poulsen

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiovascular Inflammation

Inflammation plays a significant role in the development of cardiovascular diseases, an understanding of these endogenous processes is critical for evaluating the risks and potential treatment strategies. Discover the latest research on cardiovascular inflammation here.

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

CV Disorders & Type 2 Diabetes

This feed focuses on the association of cardiovascular diseases in patients with type 2 diabetes.

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.

Cardiovascular Disorder in Diabetes

Diabetes is associated with an increased risk of cardiovascular disorders and heart failure. Discover the latest research here.