Platelets are an unindicted culprit in the development of endometriosis: clinical and experimental evidence

Human Reproduction
Ding DingSun-Wei Guo

Abstract

Do platelets play any role in the development of endometriosis? Activated platelets aggregate in endometriotic lesions and play important roles in the development of endometriosis. Platelets play important roles in cancer development and metastasis but there is no published study on their role in the development of endometriosis, even though endometriotic lesions undergo repeated cycles of tissue injury and repair, which characteristically involve platelets. Cross-sectional clinical studies of women with and without endometriosis, in vitro experimentation, and animal studies using platelet and/or macrophage depletion. Immunohistochemistry analysis of ectopic/eutopic endometrial tissues from 58 women with and 47 without endometriosis. Proliferation assay, cell cycle analysis by flow cytometry, gene expression and protein analysis for COX-2, VEGF, MMP-9, and Bcl-2 using primary cell culture, and evaluation of the rate of platelet activation induced by peritoneal fluid from women with and without endometriosis. Two mouse experiments, one that evaluated the effect of platelet depletion on lesion development and its associated phenotypic changes, and the other, the effect of platelet and/or macrophage depletion. We found that platel...Continue Reading

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Citations

Mar 8, 2016·American Journal of Obstetrics and Gynecology·Qiqi LongSun-Wei Guo
Feb 16, 2015·Fertility and Sterility·Sun-Wei GuoXishi Liu
Jul 16, 2016·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Dingmin YanSun-Wei Guo
Aug 16, 2016·Reproductive Biomedicine Online·Sun-Wei GuoXishi Liu
Sep 13, 2016·Expert Opinion on Pharmacotherapy·Giuseppe BenagianoIvo Brosens
Oct 12, 2016·Reproductive Biology and Endocrinology : RB&E·Bo ZhuSun-Wei Guo
Oct 1, 2016·Reproductive Sciences·Dingmin YanSun-Wei Guo
Apr 3, 2016·Reproductive Sciences·Ivo BrosensGiuseppe Benagiano
Feb 24, 2015·Reproductive Sciences·Qinjiao WuSun-Wei Guo
Jan 13, 2018·Reproductive Sciences·Xishi LiuSun-Wei Guo
Jun 13, 2018·Human Reproduction Update·Sun-Wei Guo, Patrick G Groothuis
Sep 25, 2018·Reproductive Sciences·Ding DingSun-Wei Guo
Apr 14, 2020·The Journal of Clinical Endocrinology and Metabolism·Ding DingSun-Wei Guo
Nov 1, 2018·Reproductive Medicine and Biology·Sun-Wei Guo
Dec 19, 2018·Human Reproduction·Dingmin YanSun-Wei Guo
Mar 4, 2019·Cellular and Molecular Life Sciences : CMLS·Wen-Jie ZhouMing-Qing Li
Jan 31, 2020·The AAPS Journal·Joel A MathewsGreta Wegner
Jun 14, 2019·Current Opinion in Obstetrics & Gynecology·Justin TanMohamed A Bedaiwy
Feb 20, 2021·Reproductive Biology and Endocrinology : RB&E·Xiaofang XuSun-Wei Guo
Jun 1, 2017·Reproductive Sciences·Dingmin YanSun-Wei Guo
Jul 28, 2020·Reproductive Biomedicine Online·Dingmin YanSun-Wei Guo
Aug 20, 2020·The Journal of Clinical Endocrinology and Metabolism·Dingmin YanSun-Wei Guo

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