Platelets are deposited early post-operatively on the leaflet of a mechanical heart valve in sheep without post-operative anticoagulants or antiplatelet agents. A scanning electron microscopic observation of the pyrolytic carbon surface in a mechanical heart valve

ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs
Y OkazakiH Harasaki

Abstract

Pyrolytic carbon has been used for mechanical heart valves as a thromboresistant, wear resistant, and fatigue resistant material. Thrombosis and thromboembolism, however, remain major mechanical heart valve associated complications and may frequently occur during the early post-operative period. In depth morphologic studies on blood-pyrolytic carbon surface interactions are limited. The purpose of this study was to evaluate the blood compatibility of the pyrolytic carbon surface of St. Jude Medical mechanical heart valves that were implanted in the mitral position of sheep without the administration of post-operative anticoagulants or antiplatelet agents for 2, 4, and 6 weeks. Almost the entire leaflet and orifice ring surfaces were observed by scanning electron microscopy. Although the surfaces appeared clean macroscopically, when observed by electron microscopy, the surface were mottled, mainly by solitary platelets and aggregations. There were only a few leukocytes or red blood cells observed. No fibrin clots were observed on the leaflets. The density of platelet deposition was higher in the vicinity of the pivots and near the edges of the leaflets. The sizes of the platelet aggregations decreased with longer duration. The o...Continue Reading

Citations

Mar 24, 2007·Journal of Biomedical Materials Research. Part a·Steven L GoodmanAvrom M Brendzel
Dec 19, 2008·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Michael ScharfschwerdtHans-H Sievers
Jul 3, 1998·Artificial Organs·Y Nosé
Aug 27, 1999·Artificial Organs·T W FossumM E DeBakey
Feb 1, 2003·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Manabu SatoAndre S Lee
Jan 24, 2009·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Hongbo ZhangRobert Guidoin
May 20, 2020·Platelets·Maurizio TomaiuoloTimothy J Stalker
Jul 9, 1999·Journal of Biomedical Materials Research·S L Goodman
Jul 27, 1999·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·H S TranA J DelRossi

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