Platelets harbor prostate cancer biomarkers and the ability to predict therapeutic response to abiraterone in castration resistant patients.

The Prostate
Lee-Ann Tjon-Kon-FatRolf Jonas Andreas Nilsson

Abstract

Novel therapies for castration resistant prostate cancer (CRPC) have been introduced in the clinic with possibilities for individualized treatment plans. Best practice of those expensive drugs requires predictive biomarker monitoring. This study used circulating biomarker analysis to follow cancer-derived transcripts implicated in therapy resistance. The isolated platelet population of blood samples and digital-PCR were used to identify selected biomarker transcripts in patients with CRPC prior chemo- or androgen synthesis inhibiting therapy. Fifty patients received either docetaxel (n = 24) or abiraterone (n = 26) therapy, with therapy response rates of 54% and 48%, respectively. Transcripts for the PC-associated biomarkers kallikrein-related peptidase-2 and -3 (KLK2, KLK3), folate hydrolase 1 (FOLH1), and neuropeptide-Y (NPY) were uniquely present within the platelet fraction of cancer patients and not detected in healthy controls (n = 15). In the abiraterone treated cohort, the biomarkers provided information on therapy outcome, demonstrating an association between detectable biomarkers and short progression free survival (PFS) (FOLH1, P < 0.01; KLK3, P < 0.05; and NPY, P < 0.05). Patients with biomarker-negative platelets h...Continue Reading

References

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Citations

Apr 21, 2018·International Journal of Molecular Sciences·Shike WangRen Xu
Mar 6, 2019·Blood·Sjors G J G In 't Veld, Thomas Wurdinger
Oct 3, 2019·Expert Review of Molecular Diagnostics·Emmy BoerrigterJack A Schalken
Jul 28, 2020·International Journal of Molecular Sciences·Magdalena ŻmigrodzkaAnna Winnicka
May 8, 2018·Frontiers in Oncology·Preeti Kanikarla-MarieDavid G Menter
Jan 12, 2019·EJNMMI Physics·Kristina SandgrenAnders Widmark
Feb 6, 2020·Proceedings of the National Academy of Sciences of the United States of America·Gaofeng XiongRen Xu
Jun 4, 2020·International Journal of Clinical Oncology·Wataru FukuokayaShin Egawa
Nov 22, 2020·Molecular Oncology·Mafalda Antunes-FerreiraThomas Würdinger
Dec 20, 2020·International Journal of Molecular Sciences·Melania DovizioPaola Patrignani
Mar 7, 2021·Genes·Ivana MartinsIsabel Marques Carreira
Mar 9, 2021·Frontiers in Cell and Developmental Biology·Nouran AbualsaudJoanna Kitlinska
May 4, 2021·Blood·Silvia D'AmbrosiThomas Wurdinger
Aug 14, 2021·Seminars in Oncology·Abhishek MohantyChinmaya Pani
Feb 21, 2019·Acta Cytologica·Susana Junqueira-NetoSónia A Melo

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