Platelets mediate protective neuroinflammation and promote neuronal plasticity at the site of neuronal injury

Brain, Behavior, and Immunity
Marina DukhinovaEugene D Ponomarev

Abstract

It is generally accepted that inflammation within the CNS contributes to neurodegeneration after traumatic brain injury (TBI), but it is not clear how inflammation is initiated in the absence of infection and whether this neuroinflammation is predominantly beneficial or detrimental. We have previously found that brain-enriched glycosphingolipids within neuronal lipid rafts (NLR) induced platelet degranulation and secretion of neurotransmitters and pro-inflammatory factors. In the present study, we compared TBI-induced inflammation and neurodegeneration in wild-type vs. St3gal5 deficient (ST3-/-) mice that lack major CNS-specific glycosphingolipids. After TBI, microglial activation and CNS macrophage infiltration were substantially reduced in ST3-/- animals. However, ST3-/- mice had a larger area of CNS damage with marked neuronal/axonal loss. The interaction of platelets with NLR stimulated neurite growth, increased the number of PSD95-positive dendritic spines, and intensified neuronal activity. Adoptive transfer and blocking experiments provide further that platelet-derived serotonin and platelet activating factor plays a key role in the regulation of sterile neuroinflammation, hemorrhage and neuronal plasticity after TBI.

Citations

Oct 19, 2019·Research and Practice in Thrombosis and Haemostasis·Leah M WuescherRandall G Worth
Dec 7, 2019·Stem Cell Reviews and Reports·Jiaying YuanXuehong Liu
May 21, 2020·Frontiers in Immunology·Odette Leiter, Tara L Walker
Nov 5, 2019·Frontiers in Cellular Neuroscience·Tatyana VeremeykoEugene D Ponomarev
Oct 31, 2020·Frontiers in Immunology·Elias RawishHarald F Langer
May 25, 2021·Epilepsy Currents·Susan Nguyen, Viji Santhakumar
Jun 30, 2021·Neurochemistry International·Ivan A LindhoutAndis Klegeris
Aug 8, 2021·British Journal of Pharmacology·Flóra GölöncsérBeáta Sperlágh
Oct 9, 2021·Seminars in Thrombosis and Hemostasis·Martin J Page, Etheresia Pretorius

❮ Previous
Next ❯

Related Concepts

Related Feeds

Brain Injury & Trauma

brain injury after impact to the head is due to both immediate mechanical effects and delayed responses of neural tissues.