Platelets play an essential role in murine lung development through Clec-2/podoplanin interaction.

Blood
Nagaharu TsukijiKatsue Suzuki-Inoue

Abstract

Platelets participate in not only thrombosis and hemostasis but also other pathophysiological processes, including tumor metastasis and inflammation. However, the putative role of platelets in the development of solid organs has not yet been described. Here, we report that platelets regulate lung development through the interaction between the platelet-activation receptor, C-type lectin-like receptor-2 (Clec-2; encoded by Clec1b), and its ligand, podoplanin, a membrane protein. Clec-2 deletion in mouse platelets led to lung malformation, which caused respiratory failure and neonatal lethality. In these embryos, α-smooth muscle actin-positive alveolar duct myofibroblasts (adMYFs) were almost absent in the primary alveolar septa, which resulted in loss of alveolar elastic fibers and lung malformation. Our data suggest that the lack of adMYFs is caused by abnormal differentiation of lung mesothelial cells (luMCs), the major progenitor of adMYFs. In the developing lung, podoplanin expression is detected in alveolar epithelial cells (AECs), luMCs, and lymphatic endothelial cells (LECs). LEC-specific podoplanin knockout mice showed neonatal lethality and Clec1b-/--like lung developmental abnormalities. Notably, these Clec1b-/--like l...Continue Reading

References

Mar 1, 1997·Experimental Lung Research·T J MarianiR A Pierce
Sep 6, 2000·American Journal of Respiratory Cell and Molecular Biology·D P WendelD Y Li
Jul 28, 2006·BMC Developmental Biology·Guetchyn MillienMaria I Ramirez
Jul 10, 2007·The Journal of Biological Chemistry·Katsue Suzuki-InoueYukio Ozaki
Feb 29, 2008·Developmental Biology·Masanori HirashimaToshio Suda
Oct 17, 2008·Proceedings of the National Academy of Sciences of the United States of America·Jianwen QueBrigid L M Hogan
May 5, 2009·American Journal of Physiology. Lung Cellular and Molecular Physiology·Najmunnisa NasreenVeena B Antony
Nov 10, 2009·American Journal of Physiology. Lung Cellular and Molecular Physiology·Keli XuSean E Egan
Aug 10, 2010·Current Topics in Developmental Biology·David WarburtonEdwin Jesudason
Jan 22, 2011·Journal of Thrombosis and Haemostasis : JTH·T UlrychB H Rauch
Apr 8, 2011·American Journal of Respiratory and Critical Care Medicine·Ganesh RaghuUNKNOWN ATS/ERS/JRS/ALAT Committee on Idiopathic Pulmonary Fibrosis
Jul 2, 2011·Lancet·Talmadge E KingMoisés Selman
Jul 6, 2011·European Journal of Immunology·Diego Mourão-SáCaetano Reis e Sousa
Sep 19, 2012·Frontiers in Immunology·Jillian L AstaritaShannon J Turley
May 4, 2013·Arteriosclerosis, Thrombosis, and Vascular Biology·Patrick WijtenArjen Scholten
Jul 3, 2013·American Journal of Physiology. Lung Cellular and Molecular Physiology·Elena CanoRamón Muñoz-Chápuli
Nov 23, 2013·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Suman KarkiVeena B Antony
Dec 3, 2013·The Journal of Clinical Investigation·Paul R HessMark L Kahn
Apr 16, 2014·The Journal of Experimental Medicine·Zoltán JakusMark L Kahn
Aug 16, 2014·Wiley Interdisciplinary Reviews. Developmental Biology·Jun Yang, Jichao Chen
Aug 20, 2014·Frontiers in Physiology·Hitesh Batra, Veena B Antony
Dec 4, 2014·Blood Reviews·Ewelina M Golebiewska, Alastair W Poole
Dec 30, 2014·Transfusion Medicine Reviews·Maria Rosaria De PascaleClaudio Napoli
Oct 22, 2016·Thrombosis Journal·Yukio OzakiKatsue Suzuki-Inoue
Nov 12, 2016·American Journal of Physiology. Lung Cellular and Molecular Physiology·Robert D BennettSteven J Mentzer
Dec 29, 2016·Journal of Thrombosis and Haemostasis : JTH·T ShiraiK Suzuki-Inoue

❮ Previous
Next ❯

Citations

Mar 6, 2019·Molecular and Cellular Biology·Jochen Michael RudolphAnnegret Reinhold
Apr 23, 2019·Monoclonal Antibodies in Immunodiagnosis and Immunotherapy·Yoshikazu FurusawaYukinari Kato
Oct 4, 2019·European Journal of Immunology·Kazuya ToneGordon D Brown
Jan 3, 2019·The Journal of Clinical Investigation·Julie RayesBernhard Nieswandt
Sep 15, 2018·Blood·Mark R Looney
Oct 23, 2019·The Journal of Immunology : Official Journal of the American Association of Immunologists·Andreas Margraf, Alexander Zarbock
Oct 10, 2019·American Journal of Physiology. Lung Cellular and Molecular Physiology·Ettore LignelliRory E Morty
Jun 18, 2020·Research and Practice in Thrombosis and Haemostasis·Katsue Suzuki-Inoue, Nagaharu Tsukiji
Nov 11, 2020·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Lisandra Vila Ellis, Jichao Chen
Dec 15, 2020·Platelets·Maan H HarbiMark R Thomas
Dec 23, 2020·Blood Advances·Anthony K YeungGeorge J Murphy
Mar 29, 2021·Journal of Thrombosis and Haemostasis : JTH·Shimon OtakeKatsue Suzuki-Inoue
May 25, 2021·Frontiers in Pediatrics·Xueyu ChenFrans J Walther
Aug 8, 2021·Journal of Clinical Medicine·Akisato NishigakiHideo Wada

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.