PMID: 21808805DOI: 10.1039/c1np00010aAug 3, 2011Paper

Platensimycin and its relatives: a recent story in the struggle to develop new naturally derived antibiotics

Natural Product Reports
Muhammad SaleemKarsten Krohn

Abstract

No abstract listed.

References

Isoprenoid biosynthesis in bacteria: a novel pathway for the early steps leading to isopentenyl diphosphate

Oct 15, 1993·The Biochemical Journal·M RohmerH Sahm

Carbometalations of simple alkenes with allyldibromoborane

May 24, 2000·Organic Letters·D E Frantz, D A Singleton

Synthesis and activity of a new generation of ruthenium-based olefin metathesis catalysts coordinated with 1,3-dimesityl-4,5-dihydroimidazol-2-ylidene ligands

May 24, 2000·Organic Letters·M SchollR H Grubbs

Mechanistic Insights into the Factors Determining Exo-Endo Selectivity in the Lewis Acid-Catalyzed Diels-Alder Reaction of 1,3-Dienes with 2-Cycloalkenones

Jul 13, 2000·Organic Letters·M GeE J Corey

The first stereoselective total synthesis of quinine

Jul 18, 2001·Journal of the American Chemical Society·G StorkA Fujimoto

Activity of linezolid against levofloxacin-resistant Streptococcus pneumoniae, methicillin-resistant Staphylococcus aureus and vancomycin-resistant enterococci in Hong Kong

Oct 3, 2001·The Journal of Antimicrobial Chemotherapy·P L HoK Y Yuen

Total Synthesis of the Strychnos Alkaloids (+/-)-Akuammicine and (+/-)-Norfluorocurarine from 3a-(o-Nitrophenyl)hexahydroindol-4-ones by Nickel(0)-Promoted Double Cyclization

Jun 26, 1996·The Journal of Organic Chemistry·Daniel SoléJoan Bosch

The first general enantioselective catalytic Diels-Alder reaction with simple alpha,beta-unsaturated ketones

Mar 14, 2002·Journal of the American Chemical Society·Alan B Northrup, David W C MacMillan

An efficient approach to Aspidosperma alkaloids via [4 + 2] cycloadditions of aminosiloxydienes: stereocontrolled total synthesis of (+/-)-tabersonine. Gram-scale catalytic asymmetric syntheses of (+)-tabersonine and (+)-16-methoxytabersonine. Asymmetric syntheses of (+)-aspidospermidine and (-)-quebrachamine

Apr 25, 2002·Journal of the American Chemical Society·Sergey A KozminViresh H Rawal

Oxidation of silyl enol ethers by using IBX and IBX.N-oxide complexes: a mild and selective reaction for the synthesis of enones

Dec 20, 2002·Angewandte Chemie·K C NicolaouScott T Harrison

Synthesis and activity of ruthenium alkylidene complexes coordinated with phosphine and N-heterocyclic carbene ligands

Feb 27, 2003·Journal of the American Chemical Society·Tina M TrnkaRobert H Grubbs

Samarium(II)-iodide-mediated cyclizations in natural product synthesis

Jul 15, 2004·Chemical Reviews·David J EdmondsDavid J Procter

Catalytic asymmetric intramolecular Michael reaction of aldehydes

Jul 27, 2004·Angewandte Chemie·Maria T Hechavarria Fonseca, Benjamin List

Nucleophilic carbenes in asymmetric organocatalysis

Aug 18, 2004·Accounts of Chemical Research·Dieter Enders, Tim Balensiefer

Diastereoselective syntheses of new analogues of the farnesyltransferase inhibitor RPR 130401

Oct 9, 2004·The Journal of Organic Chemistry·Nicolas PichonJacques Maddaluno

Determination of selectivity and efficacy of fatty acid synthesis inhibitors.

Nov 2, 2004·The Journal of Biological Chemistry·Srinivas KodaliJun Wang

Synthesis of highly substituted cyclohexenes via mixed Lewis acid-catalyzed Diels-Alder reactions of highly substituted dienes and dienophiles

Apr 9, 2005·Organic Letters·Michael E JungHiufung V Chu

Total synthesis of serofendic acids A and B employing tin-free homoallyl-homoallyl radical rearrangement

Aug 27, 2005·Organic Letters·Masahiro ToyotaMasataka Ihara

Asymmetric conjugate reduction of alpha,beta-unsaturated ketones and esters with chiral rhodium(2,6-bisoxazolinylphenyl) catalysts

Sep 30, 2005·Chemistry : a European Journal·Yoshinori KanazawaHisao Nishiyama

Cysteine-derived organocatalyst in a highly enantioselective intramolecular Michael reaction

Nov 17, 2005·Journal of the American Chemical Society·Yujiro HayashiMitsuru Shoji

Regiospecific and stereoselective syntheses of (+/-)-reserpine and (-)-reserpine

Nov 17, 2005·Journal of the American Chemical Society·Gilbert StorkMasahiro Toyota

Synthesis of spirohydantoins and spiro-2,5-diketopiperazines via resin-bound cyclic alpha,alpha-disubstituted alpha-amino esters

Jan 10, 2006·Journal of Combinatorial Chemistry·George J T KusterHans W Scheeren

The ying and yang of asymmetric aminocatalysis

Feb 16, 2006·Chemical Communications : Chem Comm·Benjamin List

Platensimycin is a selective FabF inhibitor with potent antibiotic properties

May 20, 2006·Nature·Jun WangSheo B Singh

Antibacterial natural products in medicinal chemistry--exodus or revival?

Aug 2, 2006·Angewandte Chemie·Franz von NussbaumDieter Häbich

Platensimycin, a new antibiotic and "superbug challenger" from nature

Sep 5, 2006·ChemMedChem·Dieter Häbich, Franz von Nussbaum

Isolation, structure, and absolute stereochemistry of platensimycin, a broad spectrum antibiotic discovered using an antisense differential sensitivity strategy

Sep 7, 2006·Journal of the American Chemical Society·Sheo B SinghJun Wang

An old pathway to new antibiotics--platensimycin

Oct 3, 2006·Pharmazie in unserer Zeit·Ulrike HolzgrabeIlse Zündorf

Total synthesis of platensimycin

Oct 3, 2006·Angewandte Chemie·K C NicolaouDavid J Edmonds

Stepwise acid-promoted double-Michael process: an alternative to Diels-Alder cycloadditions for hindered silyloxydiene-dienophile pairs

Jan 16, 2007·Organic Letters·Michael E Jung, David G Ho

Formal synthesis of (+/-)-platensimycin

Apr 5, 2007·Organic Letters·Yefen ZouBarry B Snider

Asymmetric total syntheses of platensimycin

Apr 21, 2007·Angewandte Chemie·K C NicolaouG Scott Tria

Discovery of platencin, a dual FabF and FabH inhibitor with in vivo antibiotic properties

Apr 26, 2007·Proceedings of the National Academy of Sciences of the United States of America·Jun WangSheo B Singh

Isolation and structure of platencin: a FabH and FabF dual inhibitor with potent broad-spectrum antibiotic activity

May 10, 2007·Angewandte Chemie·Hiranthi JayasuriyaSheo B Singh

An expedient enantioselective strategy for the oxatetracyclic core of platensimycin

May 11, 2007·Organic Letters·Krishna P Kaliappan, Velayutham Ravikumar

Adamantaplatensimycin: a bioactive analogue of platensimycin

May 22, 2007·Angewandte Chemie·K C NicolaouDavid J Edmonds

Enantioselective route to platensimycin: an intramolecular Robinson annulation approach

Jul 17, 2007·Journal of the American Chemical Society·Pingfan LiHisashi Yamamoto

Formal synthesis of (+/-)-platensimycin

Aug 19, 2007·Chemical Communications : Chem Comm·K C NicolaouJianhua Wang

Enantioselective synthesis of (-)-platensimycin oxatetracyclic core by using an intramolecular Diels-Alder reaction

Sep 4, 2007·Organic Letters·Arun K Ghosh, Kai Xi

Protecting-group-free formal synthesis of platensimycin

Sep 15, 2007·Angewandte Chemie·Konrad Tiefenbacher, Johann Mulzer

An effective enantioselective route to the platensimycin core

Oct 13, 2007·Organic Letters·Gojko Lalic, E J Corey

Total synthesis and antibacterial properties of carbaplatensimycin

Nov 9, 2007·Journal of the American Chemical Society·K C NicolaouAna Montero

Biosynthetic studies of platensimycin

Nov 24, 2007·Journal of the American Chemical Society·Kithsiri B HerathSheo B Singh

A chiral pool based synthesis of platensimycin

Jan 8, 2008·Angewandte Chemie·K C NicolaouDavid Y-K Chen

Total synthesis of platencin

Feb 5, 2008·Angewandte Chemie·K C NicolaouDavid J Edmonds

Synthesis of platensimycin

Mar 11, 2008·Angewandte Chemie·Konrad Tiefenbacher, Johann Mulzer

Structure and semisynthesis of platensimide A, produced by Streptomyces platensis

Apr 9, 2008·Organic Letters·Kithsiri B HerathSheo B Singh

A carbonyl ylide cycloaddition approach to platensimycin

Apr 17, 2008·Angewandte Chemie·Chan Hyuk KimEun Lee

Total synthesis of (+/-)-platencin

May 6, 2008·Angewandte Chemie·Joji Hayashida, Viresh H Rawal

Concise synthesis of the tricyclic core of platencin

Jun 13, 2008·Angewandte Chemie·Sang Young YunDaesung Lee

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Citations

Intercepting Wacker intermediates with arenes: C-H functionalization and dearomatization.

Nov 11, 2011·Organic Letters·Bryan S MatsuuraCorey R J Stephenson

Isolation and structural elucidation of glucoside congeners of platencin from Streptomyces platensis SB12600

Jan 31, 2013·The Journal of Antibiotics·Zhiguo YuBen Shen

Review of Platensimycin and Platencin: Inhibitors of β-Ketoacyl-acyl Carrier Protein (ACP) Synthase III (FabH)

Sep 26, 2015·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ruofeng ShangJiatu Wang

A Review on Platensimycin: A Selective FabF Inhibitor

Mar 5, 2016·International Journal of Medicinal Chemistry·Manik DasKuntal Manna

Mechanisms of self-resistance in the platensimycin- and platencin-producing Streptomyces platensis MA7327 and MA7339 strains

Feb 25, 2014·Chemistry & Biology·Ryan M PetersonBen Shen

Navigating the Chiral Pool in the Total Synthesis of Complex Terpene Natural Products

Mar 16, 2017·Chemical Reviews·Zachary G BrillThomas J Maimone

In vivo instability of platensimycin and platencin: Synthesis and biological evaluation of urea- and carbamate-platensimycin

Feb 27, 2017·Bioorganic & Medicinal Chemistry·Liao-Bin DongBen Shen

Total synthesis of (-)-platensimycin by advancing oxocarbenium- and iminium-mediated catalytic methods

Jul 23, 2014·Chemistry : a European Journal·Stanley T-C Eey, Martin J Lear

A Facile Semi-Synthetic Approach towards Halogen-Substituted Aminobenzoic Acid Analogues of Platensimycin

Jun 20, 2017·Tetrahedron·Lin QiuYong Huang

Total synthesis and preliminary SAR study of (±)-merochlorins A and B

Oct 27, 2015·Organic & Biomolecular Chemistry·Hongzhi YangYefeng Tang

Enantioselective Oxidative (4+3) Cycloadditions between Allenamides and Furans through Bifunctional Hydrogen-Bonding/Ion-Pairing Interactions

Jul 4, 2017·Angewandte Chemie·Laura VillarJose L Vicario

Recent advances in the synthesis of natural multifunctionalized decalins

Apr 22, 2015·Natural Product Reports·S DhambriJ Ardisson

Strained alkenes in natural product synthesis

Mar 2, 2013·Angewandte Chemie·Matthew R Wilson, Richard E Taylor

A chemoenzymatic and fully stereocontrolled total synthesis of the antibacterial natural product (-)-platencin

Nov 14, 2014·Chemistry, an Asian Journal·Ee Ling ChangAnthony C Willis

Enantioselective Synthesis of the Platensimycin Core by Silver(I)-Promoted Cyclization of Δ6 -α-Iodoketone

Feb 5, 2019·Chemistry : a European Journal·Milos TrajkovicFilip Bihelovic

A new route to platencin via decarboxylative radical cyclization

Nov 2, 2014·Chemical Communications : Chem Comm·Gamal A I MoustafaTakehiko Yoshimitsu

Semisynthesis and Biological Evaluation of Platensimycin Analogues with Varying Aminobenzoic Acids

Nov 30, 2018·ChemistrySelect·Kai TianYong Huang

Design and Synthesis of Molecular Scaffolds with Anti-infective Activity

Jun 11, 2016·Tetrahedron·Junjia LiuErik J Sorensen

Stereoselective approach to the racemic oxatetracyclic core of platensimycin

Feb 5, 2013·The Journal of Organic Chemistry·Sakuya HoriiShigefumi Kuwahara

Iodobenzene-catalyzed oxabicyclo[3.2.1]octane and [4.2.1]nonane synthesis via cascade C-O/C-C formation

Nov 7, 2013·Organic Letters·Marsewi NgatiminDavid W Lupton

Total synthesis of (±)-cafestol: a late-stage construction of the furan ring inspired by a biosynthesis strategy

Apr 2, 2014·Organic Letters·Lili ZhuRan Hong

Platensimycin-Encapsulated Poly(lactic-co-glycolic acid) and Poly(amidoamine) Dendrimers Nanoparticles with Enhanced Anti-Staphylococcal Activity in Vivo.

Apr 15, 2020·Bioconjugate Chemistry·Xingyun LiuYong Huang

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