Platinized graphene fiber electrodes uncover direct spleen-vagus communication.

Communications Biology
Maria A González-GonzálezMario Romero-Ortega

Abstract

Neural interfacing nerve fascicles along the splenic neurovascular plexus (SNVP) is needed to better understand the spleen physiology, and for selective neuromodulation of this major organ. However, their small size and anatomical location have proven to be a significant challenge. Here, we use a reduced liquid crystalline graphene oxide (rGO) fiber coated with platinum (Pt) as a super-flexible suture-like electrode to interface multiple SNVP. The Pt-rGO fibers work as a handover knot electrodes over the small SNVP, allowing sensitive recording from four splenic nerve terminal branches (SN 1-4), to uncover differential activity and axon composition among them. Here, the asymmetric defasciculation of the SN branches is revealed by electron microscopy, and the functional compartmentalization in spleen innervation is evidenced in response to hypoxia and pharmacological modulation of mean arterial pressure. We demonstrate that electrical stimulation of cervical and sub-diaphragmatic vagus nerve (VN), evokes activity in a subset of SN terminal branches, providing evidence for a direct VN control over the spleen. This notion is supported by adenoviral tract-tracing of SN branches, revealing an unconventional direct brain-spleen proje...Continue Reading

References

Jan 1, 1990·Annals of the New York Academy of Sciences·D L BellingerD L Felten
Dec 1, 1989·Brain, Behavior, and Immunity·D L BellingerD L Felten
Dec 1, 1989·Brain, Behavior, and Immunity·D M Nance, J Burns
Jan 1, 1987·Journal of Neuroscience Research·K D AckermanD L Felten
Feb 1, 1993·Journal of the Autonomic Nervous System·H R Berthoud, T L Powley
Mar 20, 2002·The Journal of Experimental Medicine·Thomas R BernikKevin J Tracey
Dec 20, 2002·Nature·Kevin J Tracey
Oct 8, 2005·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Karli Moncrief, Susan Kaufman
May 1, 2007·Brain, Behavior, and Immunity·Dwight M Nance, Virginia M Sanders
Aug 2, 2008·Proceedings of the National Academy of Sciences of the United States of America·Mauricio Rosas-BallinaKevin J Tracey
Feb 23, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Gergely VidaLuis Ulloa
Sep 17, 2011·Science·Mauricio Rosas-BallinaKevin J Tracey
Nov 29, 2011·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·C CailottoG E Boeckxstaens
Jan 10, 2012·Annual Review of Immunology·Ulf Andersson, Kevin J Tracey
Jun 5, 2012·Experimental Physiology·Bashair M Mussa, Anthony J M Verberne
Jun 12, 2013·The Journal of Comparative Neurology·Laurent GautronJoel K Elmquist
Jul 7, 2016·Proceedings of the National Academy of Sciences of the United States of America·Frieda A KoopmanPaul P Tak
Jan 17, 2017·Nature Neuroscience·Valentin A Pavlov, Kevin J Tracey
Sep 17, 2017·Scientific Reports·Grant A McCallumDominique M Durand
May 8, 2018·Proceedings of the National Academy of Sciences of the United States of America·Theodoros P ZanosChad E Bouton
Dec 30, 2018·Brain, Behavior, and Immunity·Thomas J M VerlindenS Eleonore Köhler
Feb 26, 2019·Advanced Materials·Kezhong WangGordon Wallace
Feb 18, 2020·Neuroscience and Biobehavioral Reviews·Gabriel S BassiLuis Ulloa
Mar 15, 2018·Bioelectronic Medicine·Harold A SilvermanKevin J Tracey

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.