Platinum analogue combination chemotherapy: cisplatin and carboplatin--a phase I trial with pharmacokinetic assessment of the effect of cisplatin administration on carboplatin excretion

Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
D L TrumpD C Tormey

Abstract

Cisplatin (NSC 119875) and carboplatin (NSC 241240) are platinum (II) analogues with very different spectra of toxicity. Cisplatin dose is limited by nausea and vomiting, renal dysfunction, and dose-related peripheral neuropathy, whereas carboplatin is myelosuppressive. There are also clinical and laboratory data that suggest that these drugs may not be completely cross-resistant. Therefore, the following phase I trial of combination therapy with cisplatin and carboplatin was undertaken. Since carboplatin toxicity is enhanced in the presence of renal impairment, carboplatin excretion was also evaluated in selected patients at the maximum tolerated dose. Thirty-three patients received 50 mg/m2 cisplatin and doses of carboplatin between 160 mg/m2 and 400 mg/m2. Sequential 20-minute infusions of carboplatin and then cisplatin were able to be administered at the standard doses of carboplatin (320 and 400 mg/m2) with thrombocytopenia to the degree expected if carboplatin alone had been given. However, 280 mg/m2 carboplatin followed by 25 mg/m2 cisplatin/d X 3 caused unexpectedly severe thrombocytopenia in seven of eight patients (median platelet nadir 45,000/microL; range, 12 to 321,000/microL; nadir was less than 90,000 in seven of...Continue Reading

Citations

Sep 29, 2018·Molecular and Cellular Biochemistry·Yasmeen GoyalPavitra Ranawat
Dec 1, 1992·Italian Journal of Neurological Sciences·A BoiardiG Broggi
Feb 1, 1997·American Journal of Clinical Oncology·R NakanishiK Yasumoto
Jan 1, 1991·Cancer Investigation·R H HrubanJ K Boitnott
Jan 1, 1995·Cancer Chemotherapy and Pharmacology·E GamelinF Larra
Jan 1, 1992·Cancer Investigation·R J Schilder, R F Ozols
Mar 10, 2001·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·M. SuzukiI. Sato
Jan 1, 1992·Cancer Chemotherapy and Pharmacology·R P PerezT C Hamilton
Jul 3, 2021·European Journal of Medicinal Chemistry·Talita Kuijpers, Burgert Blom

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anemia

Anemia develops when your blood lacks enough healthy red blood cells. Anemia of inflammation (AI, also called anemia of chronic disease) is a common, typically normocytic, normochromic anemia that is caused by an underlying inflammatory disease. Here is the latest research on anemia.