Platinum-Based Chemotherapy in Older Patients with Non-Small Cell Lung Cancer: What to Expect in the Real World

Drugs & Aging
Giacomo PelizzariAlessandro Follador

Abstract

The role of platinum-based chemotherapy (PBC) for the treatment of older patients with non-small cell lung cancer (NSCLC) is still a matter of debate, despite the advent of immunotherapy. The aim of the study was to identify factors associated with first-line PBC prescription and, secondly, to evaluate the impact of first-line PBC on survival, treatment intensity, risk of hospitalization, and subsequent treatments. We reviewed a consecutive series of 474 older patients (age ≥ 70 years) diagnosed with stage IIIB-IV NSCLC at the Department of Oncology, University Hospital of Udine, Italy from January 2009 to March 2017. Overall, 198 patients were deemed eligible, and 65.2% received a PBC. At multivariate analysis, older age was the only factor associated with PBC prescription. In the whole cohort, 46 patients (23.2%) were hospitalized for chemotherapy-related toxicity. Both PBC prescription (odds ratio [OR] 2.23, 95% confidence interval [CI] 1.02-4.87, p = 0.04) and tumor burden (OR 2.39, 95% CI 1.07-5.32, p = 0.03) emerged as independent risk factors for hospitalization. Moving to significant predictors of patterns of care, Eastern Cooperative Oncology Group (ECOG) performance status > 0 was associated with greater risk of first...Continue Reading

References

Nov 1, 1994·Journal of Clinical Epidemiology·M CharlsonJ Gold
Jul 8, 2000·The Oncologist·L Balducci, M Extermann
Jan 1, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Timothy R AsmisUNKNOWN National Cancer Institute of Canada Clinical Trials Group
Mar 10, 2010·Annals of Oncology : Official Journal of the European Society for Medical Oncology·D HardyX L Du
Mar 31, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Amy J DavidoffMartin J Edelman
Jun 12, 2014·Annals of Oncology : Official Journal of the European Society for Medical Oncology·C ChaoV M Chia
Jun 18, 2014·Annals of Oncology : Official Journal of the European Society for Medical Oncology·L DecosterM Extermann
Jun 24, 2014·Cancer Control : Journal of the Moffitt Cancer Center·Aaron C Denson, Amit Mahipal
Feb 24, 2015·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Julia KravchenkoIgor Akushevich
Jun 2, 2015·The New England Journal of Medicine·Julie BrahmerDavid R Spigel
Sep 29, 2015·The New England Journal of Medicine·Hossein BorghaeiJulie R Brahmer
Oct 21, 2015·The Cochrane Database of Systematic Reviews·Fábio N SantosRachel Riera
Feb 18, 2016·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Romain CorreChristos Chouaïd
Oct 11, 2016·The New England Journal of Medicine·Martin ReckUNKNOWN KEYNOTE-024 Investigators
Dec 3, 2016·São Paulo Medical Journal = Revista Paulista De Medicina·Fábio Nasser SantosRachel Riera
Mar 10, 2017·Expert Opinion on Biological Therapy·Assunta SgambatoCesare Gridelli
Apr 17, 2018·The New England Journal of Medicine·Leena GandhiUNKNOWN KEYNOTE-189 Investigators
May 22, 2018·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Supriya G MohileArti Hurria
Jun 5, 2018·The New England Journal of Medicine·Mark A SocinskiUNKNOWN IMpower150 Study Group
Jul 11, 2018·Future Oncology·Silvia Vecchiarelli, Chiara Bennati
Jul 22, 2018·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Cesare GridelliFrancesco Perrone
Aug 11, 2018·Expert Review of Respiratory Medicine·Paola C SaccoCesare Gridelli
Sep 21, 2018·American Society of Clinical Oncology Educational Book·Ravindran KanesvaranRonald Maggiore
Oct 4, 2018·The New England Journal of Medicine·Luis Paz-AresUNKNOWN KEYNOTE-407 Investigators
Oct 12, 2018·Journal of Geriatric Oncology·Lore Decoster, Denis Schallier
Feb 5, 2019·Annals of Oncology : Official Journal of the European Society for Medical Oncology·D PlanchardS Peters
Jun 7, 2019·Current Treatment Options in Oncology·Laurent MhannaJulien Mazieres
Dec 13, 2019·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·R CalifanoS Ekman
Jan 29, 2020·Annals of Oncology : Official Journal of the European Society for Medical Oncology·D PlanchardS Peters
Sep 1, 2014·Annals of Oncology : Official Journal of the European Society for Medical Oncology·C ChaoV M Chia
Mar 7, 2020·Expert Review of Anticancer Therapy·Edgardo S Santos
Oct 1, 2018·Annals of Oncology : Official Journal of the European Society for Medical Oncology·D PlanchardUNKNOWN ESMO Guidelines Committee. Electronic address: clinicalguidelines@esmo.org

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Gastroenterology
Ansgar W Lohse, Christina Weiler-Normann
Canadian Journal of Gastroenterology = Journal Canadien De Gastroenterologie
Robert P MyersHude Quan
Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association
Nikolaos K GatselisGlobal Primary Biliary Cholangitis Study Group
© 2021 Meta ULC. All rights reserved