Platinum complexes of nucleotides.

Bioinorganic Chemistry
P C Kong, T Theophanides

Abstract

The reaction of [Pt(dien)Cl1Cl (dien = NH2CH2CH2NHCH2CH2NH2) with nucleotides has been studied by nuclear magnetic resonance. It has been found that the CMP (cytidine 5'-monophosp-ate) and GMP (guanosine 5'-monophosphate/coordinate to the platinum atom through N3 and N7, respectively. The reaction of the platinum salt with the nucleotide is complete when one to one ratio of platinum to nucleotide is used and no evidence of phosphate group binding to platinum has been found. No additional binding sites have been detected except the N7 site on the guanylic group of GMP even in the presence of a large excess of [Pt(dien) Cl1Cl. The AMP (adenosine 5'monophosphate] coordinates to the platinum at the N1 and/or N7 sites. The reaction of AMP and platinum is complete is complete at a ratio of four platinum to one AMP.

Citations

Aug 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·K G Strothkamp, S J Lippard
Sep 11, 1982·Nucleic Acids Research·N P JohnsonB Monsarrat
Aug 2, 2017·Journal of Environmental Science and Health. Part A, Toxic/hazardous Substances & Environmental Engineering·T Theophanides, J Anastassopoulou
Oct 25, 1979·Biochimica Et Biophysica Acta·D HermannW Guschlbauer

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