PMID: 22583420May 16, 2012Paper

Platinum compounds: a hope for future cancer chemotherapy

Anti-cancer Agents in Medicinal Chemistry
Imran AliAshanul Haque

Abstract

The discovery of cis-platin and its second and third generation analogues created a hope in cancer chemotherapy. Cis-platin and its second generation analogue carboplatin have been used for the treatment of some cancers from a long time. The third generation analogues have superior anti-cancer profiles for curing a few cancers. Unfortunately, certain side effects such as renal impairment, neurotoxicity and ototoxicity etc. are associated with these drugs. But, combination therapy makes these analogues more effective with fewer side effects. In addition, the results of some ongoing clinical trials will make the safety profile clear in near future. The present article describes the current status of cis-platin and its analogues in cancer chemotherapy. In addition, special emphasis has been made on cis-platin discovery, development of second (carboplatin, oxaliplatin, nedaplatin) and third (lobaplatin, heptalatin) generation analogues, comparison of their chemotherapies, mechanism of action, therapeutic status, recent developments and chronology. Moreover, attempts have been made to describe the future perspectives of these drugs in the cancer treatment.

Citations

Jun 19, 2013·Trends in Pharmacological Sciences·Thorsten LangerOliver Zolk
May 21, 2013·Future Medicinal Chemistry·Imran AliKishwar Saleem
Nov 2, 2013·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Hao ZhangWeihao Sun
Feb 6, 2016·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Xiaopin DuanWenbin Lin
Mar 5, 2016·European Journal of Pharmacology·George LiamisMoses S Elisaf
Jul 12, 2013·Biomedical Chromatography : BMC·Imran AliMohammed Al Za'abi
Apr 21, 2016·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Qinqin Cheng, Yangzhong Liu
May 18, 2016·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·H-T WuY Li
Jun 5, 2016·Fitoterapia·Sheikh ShreazLee Ting Hun
Jul 5, 2016·Regulatory Toxicology and Pharmacology : RTP·Adriana GrozavDaniela-Saveta Popa
Oct 13, 2016·International Journal of Pediatric Otorhinolaryngology·Yüksel OlgunEnis Alpin Güneri
Jul 20, 2017·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Amina MedhatMustafa Mahmoud
May 12, 2018·Clinical and Experimental Pharmacology & Physiology·Gülüzar ÖzbolatAbdullah Tuli
Nov 18, 2018·Journal of Microencapsulation·Eskandar MoghimipourSomayeh Handali
Mar 9, 2019·Combinatorial Chemistry & High Throughput Screening·Mei-Chen ZhangFeng Jiang
Nov 20, 2018·Anti-cancer Agents in Medicinal Chemistry·Rafa S AlmeerAhmed E Abdel Moneim
Nov 23, 2018·Anti-cancer Agents in Medicinal Chemistry·Xue-Qing ZhangChen Luo
Mar 5, 2019·Anti-cancer Agents in Medicinal Chemistry·Habib ZarredarMilad Asadi
Nov 8, 2017·Acta Crystallographica. Section C, Structural Chemistry·Tatsuto KiwadaAkira Odani
Mar 15, 2015·The Oncologist·Abolfazl AvanGodefridus J Peters
May 14, 2014·Anti-cancer Drugs·Florian FunkGerhard Fritz
Oct 3, 2018·Future Medicinal Chemistry·Aleksandra KładnaHassan Y Aboul-Enein
Apr 10, 2014·Chemistry : a European Journal·Jesús Ceballos-TorresSantiago Gómez-Ruiz
Aug 7, 2015·Toxics·Alessia ChiorazziPaola Marmiroli
Feb 27, 2014·Asian Pacific Journal of Cancer Prevention : APJCP·Nan WangJia-Rui Li
Jun 21, 2019·Dose-response : a Publication of International Hormesis Society·Hongwen CaoChao Yu

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Postȩpy higieny i medycyny doświadczalnej
K Waszkiewicz
Anti-cancer Agents in Medicinal Chemistry
Jinchao ZhangYing Zhang
Dalton Transactions : an International Journal of Inorganic Chemistry
Nial J WheateRabbab Oun
© 2021 Meta ULC. All rights reserved