Platinum corrosion products from electrode contacts of human cochlear implants induce cell death in cell culture models

PloS One
Kirsten WisselMartin Durisin

Abstract

Despite the technological progress made with cochlear implants (CI), impedances and their diagnosis remain a focus of interest. Increases in impedance have been related to technical defects of the electrode as well as inflammatory and/or fibrosis along the electrode. Recent studies have demonstrated highly increased impedances as the result of corroded platinum (Pt) electrode contacts. This in vitro study examined the effects of Pt ions and compounds generated by corrosion of the electrode contacts of a human CI on cell metabolism. Since traces of solid Pt in surrounding cochlear tissues have been reported, the impact of commercially available Pt nanoparticles (Pt-NP, size 3 nm) on the cell culture model was also determined. For this purpose, the electrode contacts were electrically stimulated in a 0.5% aqueous NaCl solution for four weeks and the mass fraction of the platinum dissolute (Pt-Diss) was determined by mass spectrometry (ICP-MS). Metabolic activity of the murine fibroblasts (NIH 3T3) and the human neuroblastoma (SH-SY5Y) cells was determined using the WST-1 assay following exposure to Pt-Diss and Pt-NP. It was found that 5-50 μg/ml of the Pt-NP did not affect the viability of both cell types. In contrast, 100 μg/ml ...Continue Reading

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Citations

Apr 12, 2020·Analytical and Bioanalytical Chemistry·Daniel P HeineckMichael Heller
Aug 8, 2020·Journal of Neural Engineering·Nicholas V ApolloFlavia Vitale
Nov 17, 2020·Frontiers in Neuroscience·Andrzej PepłowskiMałgorzata Jakubowska
May 22, 2021·Acta Biomaterialia·Poppy Oldroyd, George Malliaras

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Methods Mentioned

BETA
scanning electron microscopy
transmission electron microscopy
cochlear implant
light microscopy

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