Platinum-doped carbon nanoparticles inhibit cancer cell migration under mild laser irradiation: Multi-organelle-targeted photothermal therapy

Biomaterials
Yan-Wen BaoFu-Gen Wu

Abstract

Tumor growth and metastasis are two main causes of cancer-related deaths. Here, we simultaneously investigated the effects of nanoparticles on cancer cell viability and migration using polyethylene glycol (PEG)-modified, platinum-doped (<4 mol %) carbon nanoparticles (denoted as PEG-PtCNPs). The bare PtCNPs were prepared by the facile one-step hydrothermal treatment of p-phenylenediamine and K2PtCl4 in aqueous solution. After PEGylation, the obtained PEG-PtCNPs can serve as an excellent photothermal nanoagent for cell migration inhibition, laser-triggered nuclear delivery, effective tumor accumulation, and imaging-guided tumor ablation with improved therapeutic efficacy and reduced side effects. In the absence of laser exposure, the positively charged PEG-PtCNPs with a hydrodynamic diameter of ∼19 nm easily entered the cells by endocytosis and were located in multiple organelles (including mitochondrion, endoplasmic reticulum, lysosome, and Golgi apparatus), causing a slight increase in the expression level of nuclear protein lamin A/C. Upon mild laser irradiation (0.3 W cm-2), the fragmented cytoskeletal structures and overexpression of lamin A/C were observed, thus inhibiting cancer cell migration. Furthermore, hyperthermia i...Continue Reading

Citations

Jan 30, 2020·Advanced Healthcare Materials·Miguel M LeitãoIlídio J Correia
Feb 20, 2019·Molecular Biology Reports·Furkan AyazRükan Genç
Nov 14, 2018·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Guochang MaJie Lu
Jan 14, 2019·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Yan-Wen BaoFu-Gen Wu
May 28, 2021·Research : a Science Partner Journal·Xiulin YiFu-Gen Wu
Jul 22, 2021·Chemical Communications : Chem Comm·Eunbin Hwang, Hyo Sung Jung
Aug 11, 2021·Luminescence : the Journal of Biological and Chemical Luminescence·Yan ZhangGuixia Liu

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