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Platinum drugs and neurotoxicity: effects on intracellular calcium homeostasis

Cell Biology and Toxicology

Aug 29, 2013

Valeria M PiccoliniGraziella Bernocchi

Abstract

[Pt(O,O'-acac)(γ-acac)(DMS)] (PtAcacDMS) is a new platinum compound showing low reactivity with nucleobases and specific reactivity with sulfur ligands intracellularly. It induces apoptosis in breast cancer cells, but appears to be less neurotoxic to the developing cerebellum than cispl...read more

Mentioned in this Paper

Biological Markers
Buffers
Study
In Vivo
Calcium [EPC]
Ca(2+)-Transporting ATPase
Antineoplastic Agents
Calbindin 1
Crotalaria cornu-ammonis
Immunoreactivity
Paper Details
References
  • References45
  • Citations4
12345
  • References45
  • Citations4
1

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Platinum drugs and neurotoxicity: effects on intracellular calcium homeostasis

Cell Biology and Toxicology

Aug 29, 2013

Valeria M PiccoliniGraziella Bernocchi

PMID: 23982140

DOI: 10.1007/s10565-013-9252-3

Abstract

[Pt(O,O'-acac)(γ-acac)(DMS)] (PtAcacDMS) is a new platinum compound showing low reactivity with nucleobases and specific reactivity with sulfur ligands intracellularly. It induces apoptosis in breast cancer cells, but appears to be less neurotoxic to the developing cerebellum than cispl...read more

Mentioned in this Paper

Biological Markers
Buffers
Study
In Vivo
Calcium [EPC]
Ca(2+)-Transporting ATPase
Antineoplastic Agents
Calbindin 1
Crotalaria cornu-ammonis
Immunoreactivity

Similar Papers Found In These Feeds

Neurotoxicity, Inflammation & Neuroprotection

The end result of the inflammatory process, neurotoxicity and/or neuroprotection, is a function of the fine balance between the two cellular systems, i.e., of the complex signaling relationships between anti-inflammatory neuroprotective factors (neurotrophins and other chemical mediators) and proinflammatory neurotoxic factors (tnf, free radicals, certain cytokines, etc). Here are the latest discoveries pertaining to neurotoxicity, inflammation and neuroprotection.

Related Papers

Chemotherapy Research and Practice

Developing central nervous system and vulnerability to platinum compounds

Chemotherapy Research and PracticeFebruary 9, 2012
Graziella BernocchiFrancesco Paolo Fanizzi
Journal of Chemical Neuroanatomy

Developmental expression of cellular prion protein and apoptotic molecules in the rat cerebellum: effects of platinum compounds

Journal of Chemical NeuroanatomySeptember 29, 2012
Maria Grazia BottoneGraziella Bernocchi
Paper Details
References
  • References45
  • Citations4
12345
  • References45
  • Citations4
1
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