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Platinum drugs and neurotoxicity: effects on intracellular calcium homeostasis

Cell Biology and Toxicology

Oct 1, 2013

Valeria Maria PiccoliniGraziella Bernocchi

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Abstract

[Pt(O,O'-acac)(γ-acac)(DMS)] (PtAcacDMS) is a new platinum compound showing low reactivity with nucleobases and specific reactivity with sulfur ligands intracellularly. It induces apoptosis in breast cancer cells, but appears to be less neurotoxic to the developing cerebellum than cispl...read more

Mentioned in this Paper

NSC-119875
Calcium Pump Activity
Platinol
diamminechloro(9-(2-hydroxyethoxymethyl)guan-7-yl)platinum(II)
Antineoplastic Agents
Calbindin 1
Plasma
Ligands
Platinum Antineoplastic Compound
Entire Dentate Gyrus
Paper Details
References
  • References41
  • Citations4
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Platinum drugs and neurotoxicity: effects on intracellular calcium homeostasis

Cell Biology and Toxicology

Oct 1, 2013

Valeria Maria PiccoliniGraziella Bernocchi

PMID: 23982140

DOI: 10.1007/s10565-013-9252-3

Abstract

[Pt(O,O'-acac)(γ-acac)(DMS)] (PtAcacDMS) is a new platinum compound showing low reactivity with nucleobases and specific reactivity with sulfur ligands intracellularly. It induces apoptosis in breast cancer cells, but appears to be less neurotoxic to the developing cerebellum than cispl...read more

Mentioned in this Paper

NSC-119875
Calcium Pump Activity
Platinol
diamminechloro(9-(2-hydroxyethoxymethyl)guan-7-yl)platinum(II)
Antineoplastic Agents

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Paper Details
References
  • References41
  • Citations4
12345

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