Platinum(ii) non-covalent crosslinkers for supramolecular DNA hydrogels.

Chemical Science
Kaka Zhang, Vivian Wing-Wah Yam

Abstract

Manipulation of non-covalent metal-metal interactions allows the fabrication of functional metallosupramolecular structures with diverse supramolecular behaviors. The majority of reported studies are mostly designed and governed by thermodynamics, with very few examples of metallosupramolecular systems exhibiting intriguing kinetics. Here we report a serendipitous finding of platinum(ii) complexes serving as non-covalent crosslinkers for the fabrication of supramolecular DNA hydrogels. Upon mixing the alkynylplatinum(ii) terpyridine complex with double-stranded DNA in aqueous solution, the platinum(ii) complex molecules are found to first stack into columnar phases by metal-metal and π-π interactions, and then the columnar phases that carry multiple positive charges crosslink the negatively charged DNA strands to form supramolecular hydrogels with luminescence properties and excellent processability. Subsequent platinum(ii) intercalation into DNA competes with the metal-metal and π-π interactions at the crosslinking points, switching on the spontaneous gel-to-sol transition. In the case of a chloro (2,6-bis(benzimidazol-2'-yl)pyridine)platinum(ii) complex, with [Pt(bzimpy)Cl]+ serving as a non-covalent crosslinker where the met...Continue Reading

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Citations

Jun 22, 2021·Frontiers in Bioengineering and Biotechnology·Xueting JianYang Liu
Jul 9, 2021·Dalton Transactions : an International Journal of Inorganic Chemistry·Bishnu Das, Parna Gupta
Sep 22, 2021·Angewandte Chemie·Dong WangDan Luo

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Methods Mentioned

BETA
electron diffraction
X-ray
circular dichroism
NMR

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