Platycodon grandiflorum Saponins Ameliorate Cisplatin-Induced Acute Nephrotoxicity through the NF-κB-Mediated Inflammation and PI3K/Akt/Apoptosis Signaling Pathways

Nutrients
Weizhe ZhangWei Li

Abstract

Although cisplatin is a potent chemotherapeutic agent against cancers, its clinical application is seriously limited by its severe side effects of nephrotoxicity. Previous studies reported that saponins isolated from the roots of Platycodon grandiflorum (PGS) exerted protective effects in various animal models of renal injury, with no confirmation on cisplatin-induced injury. This study was designed to investigate the protective effect of PGS (15 and 30 mg/kg) on cisplatin-induced kidney injury in mice. The levels of serum creatinine (CRE) and blood urea nitrogen (BUN), and renal histopathology demonstrated the protective effect of PGS against cisplatin-induced kidney injury. PGS exerted anti-inflammation effects via suppressing nuclear factor-kappa B (NF-κB) activation and alleviating the cisplatin-induced increase in inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), tumor necrosis factor-α (TNF-α), and interleukin-1β (IL-1β) in kidney tissues. The expressions of phosphorylation of phosphatidylinositol 3-kinase/protein kinase B and its downstream apoptotic factors, such as Bcl-2 and caspase families were regulated by PGS in a dose-dependent manner. In conclusion, PGS exerted kidney protection effects against ci...Continue Reading

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Citations

Jun 23, 2019·International Journal of Molecular Sciences·Sara J HolditchCharles L Edelstein
Aug 9, 2020·Clinical and Experimental Nephrology·Wei ZhangHao Zhang
Sep 7, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Zhiyou YangCai Zhang
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Nov 30, 2019·Oxidative Medicine and Cellular Longevity·Wanfen ZhangBicheng Liu
Jan 1, 2021·BioMed Research International·Fuda XieJiangyong Gu
Jan 3, 2021·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Jun-Nan HuWei Li
Mar 23, 2021·Acta Pharmacologica Sinica·Chun-Yan FangQin-Jie Weng
Jun 24, 2020·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Yuping ZhangXiujie Sheng
Jul 1, 2020·Ecotoxicology and Environmental Safety·Jiajia HaoJianzhu Liu

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Methods Mentioned

BETA
column chromatography
light microscopy
electrophoresis

Software Mentioned

Quantity One
GraphPad Prism

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