PMID: 10648502Jan 29, 2000Paper

Platypnoea-orthodeoxia syndrome

P KublerP Garrahy


PLATYPNOEA: orthodeoxia is a rare syndrome of postural hypoxaemia accompanied by breathlessness. The predominant symptom, dyspnoea induced by upright posture, can be debilitating and difficult to discern without thorough evaluation of the patient's pattern of dyspnoea. The precise cause of the syndrome is unclear but patients develop right to left intracardiac shunting in the presence of normal right sided cardiac pressures. Initially, patients should have confirmation of orthostatic desaturation by erect and supine pulse oximetry. However, definitive diagnosis of an orthostatic intracardiac shunt is most readily established by echocardiography. The use of echocontrast with postural manoeuvres may facilitate the diagnosis. The treatment of choice is surgical closure of the intracardiac (usually interatrial) communication, which may result in dramatic symptomatic and haemodynamic improvement. Three cases (a 27 year old man and two women aged 63 and 72 years) are described that exemplify the presentation of this syndrome, and reflect the varied management strategies and outcomes of this condition.


Feb 26, 2008·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·S RichterM A Secknus
Dec 10, 2002·European Journal of Ultrasound : Official Journal of the European Federation of Societies for Ultrasound in Medicine and Biology·Gian Paolo Anzola
Sep 8, 2001·Critical Care Medicine·I M MackenzieO Dyar
Aug 11, 2004·Southern Medical Journal·Syed Fayyaz Hussain, Sabeen Fatima Mekan
Mar 12, 2005·Heart·J-C EicherJean-Eric Wolf
Jan 28, 2003·Circulation Journal : Official Journal of the Japanese Circulation Society·Nobutaka HiraiHisao Ogawa
Sep 18, 2008·Radiology·Marie-Pierre RevelJacques Remy
Dec 3, 2014·Annales de cardiologie et d'angéiologie·R CheaitoP Jessen
Dec 1, 2012·Revista Clínica Espanõla·E AmaoF Michel
Sep 26, 2013·Annales de cardiologie et d'angéiologie·L RocheJ-F Aupetit
Feb 9, 2010·Medicina clínica·Ramón BoixedaJosep Anton Capdevila
Nov 22, 2008·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Ilaria LenciRichard Steeds
Apr 3, 2007·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Géraldine BertauxJean-Eric Wolf
Mar 31, 2007·International Journal of Cardiology·Abdenasser DrighilAhmed Bennis
Oct 10, 2009·Clinical Cardiology·Vijaya SanikommuIndu Poornima
Mar 7, 2007·Journal of Cardiac Surgery·Coimbatore V SrinivasPatricia M Murphy
Sep 3, 2011·Cardiovascular Therapeutics·Bruce Irwin, Simon Ray
Sep 19, 2012·Congenital Heart Disease·M Carmen Gomez-RubinJose L Lopez-Sendon
Jan 19, 2015·Archivos de bronconeumología·Oriol Plans GalvánJuan Ruiz Manzano
Jun 30, 2015·Journal of Cardiothoracic and Vascular Anesthesia·Annalisa CarlucciGianfranco Butera
Jun 4, 2014·Echocardiography·Pawan HariPadmini Varadarajan
May 19, 2012·JACC. Cardiovascular Imaging·Yasunaga ShiraishiTakeshi Adachi
Nov 7, 2003·Anaesthesia and Intensive Care·P V van HeerdenM A Goodman
Jan 21, 2021·Texas Heart Institute Journal·Sanket P BorgaonkarDhaval R Parekh

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