PLAU Promotes Cell Proliferation and Epithelial-Mesenchymal Transition in Head and Neck Squamous Cell Carcinoma.

Frontiers in Genetics
Guangjin ChenLili Chen

Abstract

Plasminogen activator, urokinase (uPA) is a secreted serine protease whose Dysregulation is often accompanied by various cancers. However, the biological functions and potential mechanisms of PLAU in head and neck squamous cell carcinoma (HNSCC) remain undetermined. Here, the expression, prognosis, function, and coexpression genetic networks of PLAU in HNSCC were investigated by a series of public bioinformatics tools. A Higher PLAU level predicted a poorer clinical outcome. Meanwhile, functional network analysis implied that PLAU and associated genes mainly regulated cell-substrate adhesion, tissue migration, and extracellular matrix binding. The top 4 significantly associated genes are C10orf55, ITGA5, SERPINE1, and TNFRSF12A. Pathway enrichment analysis indicated that PLAU might activate the epithelial-to-mesenchymal transition (EMT) process, which could explain the poor prognosis in HNSCC. Besides, genes associated with PLAU were also enriched in EMT pathways. We further validated the bioinformatics analysis results by in vivo and in vitro experiments. Then, we found that much more PLAU was detected in HNSCC tissues, and the silencing of PLAU inhibit the proliferation, migration, and EMT process of CAL27 cell lines. Notably...Continue Reading

References

Apr 8, 2004·Neoplasia : an International Journal for Oncology Research·Daniel R RhodesArul M Chinnaiyan
Apr 21, 2005·Thrombosis and Haemostasis·Keld DanøJohn Rømer
Aug 1, 2007·The Journal of Cell Biology·Robin D LesterSteven L Gonias
Feb 8, 2008·BMC Genomics·Hui YeXiaofeng Zhou
May 20, 2008·Lancet·Athanassios ArgirisRobert L Ferris
Dec 29, 2009·FEBS Letters·Francesco Blasi, Nicolai Sidenius
Sep 22, 2010·BMJ : British Medical Journal·H MehannaC Nutting
Oct 25, 2011·Immunological Reviews·Linda C BurklyTimothy S Zheng
Apr 4, 2013·Science Signaling·Jianjiong GaoNikolaus Schultz
Apr 9, 2013·Experimental Cell Research·Eva BernhartWolfgang Sattler
Feb 20, 2014·Medicinal Research Reviews·Ahmed H MekkawyDavid L Morris
Feb 13, 2015·Cancer Research·Aaron M LeBeauHenry F VanBrocklin
Sep 10, 2015·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Assuntina G Sacco, Ezra E Cohen
Dec 17, 2015·Expert Opinion on Therapeutic Targets·Shih-Chi SuShun-Fa Yang
Jul 22, 2017·Neoplasia : an International Journal for Oncology Research·Darshan S ChandrashekarSooryanarayana Varambally
Nov 9, 2017·Nature Reviews. Clinical Oncology·Ibiayi Dagogo-Jack, Alice T Shaw
Nov 15, 2017·Nucleic Acids Research·Suhas V VasaikarBing Zhang
Dec 10, 2017·Advances in Biological Regulation·Aleksandra AdamskaMarco Falasca
May 24, 2018·Bioinformatics·Chun-Jie LiuAn-Yuan Guo
Jun 20, 2018·Developmental Cell·Nicole M AielloBen Z Stanger
Jan 21, 2019·Molecular Therapy : the Journal of the American Society of Gene Therapy·Ziyue ChenTianxin Lin
Aug 14, 2019·International Reviews of Immunology·Rucha Chandwaskar, Amit Awasthi
Jan 2, 2020·The New England Journal of Medicine·Laura Q M Chow

❮ Previous
Next ❯

Software Mentioned

GraphPad Prism
linkedOmics
LinkFinder
GEPIA
Gene Set Enrichment Analysis ( GSEA )
CBioPortal
GSCALite
UANLCAN
Oncomine

Related Concepts

Related Feeds

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.

Biophysics of Adhesion

Alterations in cell adhesion can disrupt important cellular processes and lead to a variety of diseases, including cancer and arthritis. It is also essential for infectious organisms, such as bacteria or viruses, to cause diseases. Understanding the biophysics of cell adhesion can help understand these diseases. Discover the latest research on the biophysics of adhesion here.

Cell Migration in Cancer and Metastasis

Migration of cancer cells into surrounding tissue and the vasculature is an initial step in tumor metastasis. Discover the latest research on cell migration in cancer and metastasis here.

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.

Carcinoma, Squamous Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.