Playing by different rules: the evolution of virulence in sterilizing pathogens

The American Naturalist
Kara J O'Keefe, Janis Antonovics

Abstract

We investigate the evolution of virulence of pathogens that reduce their hosts' fitness primarily by affecting host fecundity. We show that, under many conditions, such sterilizing pathogens evolve high rather than intermediate levels of virulence, and this pushes the pathogen population and sometimes the host population toward extinction. We also show that spatial population structure can reverse this evolutionary result and allow the persistence of intermediate-virulence pathogens. Thus, spatial population structure may be vital to the persistence of sterilizing pathogens in nature.

References

Aug 2, 1979·Nature·R M Anderson, R M May
Jan 1, 1989·Journal of Mathematical Biology·H J Bremermann, H R Thieme
Jul 1, 1964·Journal of Theoretical Biology·W D Hamilton
Oct 1, 1982·Parasitology·R M Anderson, R M May
Feb 7, 1983·Journal of Theoretical Biology·H J Bremermann, J Pickering
Jan 1, 1981·Annual Review of Microbiology·M Alexander
Jun 21, 1995·Journal of Theoretical Biology·M Lipsitch, M A Nowak
Oct 21, 1994·Journal of Theoretical Biology·S A Frank
Jan 22, 1994·Proceedings. Biological Sciences·M A Nowak, R M May
Jun 22, 1996·Proceedings. Biological Sciences·S BonhoefferD Ebert
Mar 1, 1996·The Quarterly Review of Biology·S A Frank
Jan 22, 1997·Proceedings. Biological Sciences·P Agnew, J C Koella
Mar 31, 1999·Proceedings. Biological Sciences·S L MessengerJ J Bull
Mar 8, 2000·Journal of Theoretical Biology·Y Haraguchi, A Sasaki
Mar 12, 2004·Annual Review of Phytopathology·K B Johnson, V O Stockwell
Mar 1, 1996·Parasitology Today·D Ebert, E A Herre
Sep 25, 2008·The American Naturalist·D R TaylorR E Lenski

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Citations

Jan 8, 2013·Bulletin of Mathematical Biology·Luděk Berec, Daniel Maxin
Jun 5, 2003·Trends in Microbiology·Sam L Elliot
Feb 9, 2012·Parasitology·H Hartikainen, B Okamura
Mar 28, 2009·Proceedings. Biological Sciences·Ian SorrellMike Boots
Jul 21, 2010·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Christal M EshelmanBenjamin Kerr
Feb 22, 2005·The New Phytologist·Janis Antonovics
Feb 22, 2005·The New Phytologist·Mark D Rausher
May 25, 2006·PLoS Biology·Knut Helge JensenDieter Ebert
May 14, 2005·Oecologia·Ellen DecaesteckerDieter Ebert
Aug 20, 2008·The American Naturalist·Samuel Alizon
Nov 13, 2004·The American Naturalist·Dieter EbertEllen Decaestecker
Oct 15, 2005·The American Naturalist·Jean-Baptiste Ferdy, Bernard Godelle
Sep 2, 2006·The American Naturalist·Matthew H Bonds
Jun 7, 2005·The American Naturalist·Samuel Alizon, Minus van Baalen
Mar 20, 2014·The American Naturalist·Gabriel E LeventhalSeth M Barribeau
Oct 3, 2015·Proceedings of the National Academy of Sciences of the United States of America·Ben Ashby, Michael Boots
Oct 6, 2009·Trends in Parasitology·Kevin D Lafferty, Armand M Kuris
Nov 4, 2008·Journal of Theoretical Biology·Jean-Baptiste Ferdy
Dec 8, 2007·Journal of Theoretical Biology·Thomas Caraco, Ing-Nang Wang
Nov 9, 2007·Journal of Theoretical Biology·Anne DeredecFranck Courchamp
Dec 17, 2014·Evolution; International Journal of Organic Evolution·Emily BrunsJanis Antonovics
Jun 6, 2009·Journal of Evolutionary Biology·C M Lively
Dec 12, 2007·Ecology Letters·Sébastien Lion, Minus van Baalen
Feb 7, 2009·Journal of Evolutionary Biology·S AlizonM Van Baalen
Sep 16, 2006·Ecology Letters·Curtis M Lively
Aug 23, 2008·Journal of Evolutionary Biology·D B SloanM E Hood
Aug 24, 2010·Ecology Letters·Sébastien Lion, Mike Boots
Jan 3, 2013·Biological Reviews of the Cambridge Philosophical Society·Grant BrearleyClive McAlpine
Dec 3, 2010·Evolution; International Journal of Organic Evolution·Manuela López-VillavicencioTatiana Giraud
Mar 20, 2010·Evolution; International Journal of Organic Evolution·Edward O JonesMichael Boots
Apr 22, 2010·The New Phytologist·Susan E MeyerSuzette Clement
Mar 4, 2015·Evolution; International Journal of Organic Evolution·Ulla Carlsson-Granér, Peter H Thrall
Apr 23, 2014·Evolution; International Journal of Organic Evolution·Ben Ashby, Sunetra Gupta
Apr 23, 2014·Journal of Evolutionary Biology·P D WilliamsA A Dhondt
Jan 1, 2014·Evolution; International Journal of Organic Evolution·Ayco J M TackAnna-Liisa Laine
Jan 31, 2006·Theoretical Population Biology·Thomas CaracoBoleslaw K Szymanski
Jul 15, 2015·Trends in Parasitology·Charlotte RafalukGerrit Joop
Feb 11, 2015·The Journal of Animal Ecology·Rony Izhar, Frida Ben-Ami
Sep 4, 2015·Proceedings. Biological Sciences·David V McLeod, Troy Day

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