Abstract
Plazomicin, a novel aminoglycoside with in vitro activity against MDR Gram-negative organisms, is under development to treat patients with serious enterobacterial infections. We evaluated the activity of plazomicin and comparators against colistin-resistant enterobacterial isolates. Susceptibility to plazomicin and comparators was tested by broth microdilution for a collection of 95 colistin-resistant enterobacterial isolates collected from 29 hospitals in eight countries. Forty-two isolates (Klebsiella pneumoniae and Klebsiella oxytoca) possessed chromosomally encoded resistance mechanisms to colistin, 21 isolates (Escherichia coli and Salmonella enterica) expressed the mcr-1 gene, 8 isolates (Serratia, Proteus, Morganella and Hafnia) were intrinsically resistant to colistin and 24 isolates (K. pneumoniae, E. coli and Enterobacter spp.) had undefined, non-mcr-1 mechanisms. Susceptibility profiles were defined according to CLSI for aminoglycosides and to EUCAST for colistin and tigecycline. Plazomicin inhibited 89.5% and 93.7% of the colistin-resistant enterobacterial isolates at ≤ 2 and ≤4 mg/L, respectively. MICs of plazomicin were ≤2 mg/L for all of the mcr-1 positive isolates and ≤4 mg/L for all the intrinsic colistin-resis...Continue Reading
References
Jul 9, 2010·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·Y ZhouM Wang
Mar 15, 2011·Diagnostic Microbiology and Infectious Disease·Laurent PoirelPatrice Nordmann
Oct 18, 2011·Diagnostic Microbiology and Infectious Disease·Béatrice BerçotPatrice Nordmann
Jan 31, 2014·Journal of Clinical Microbiology·April M BobenchikRomney M Humphries
May 6, 2014·International Journal of Antimicrobial Agents·Young-Mi AhJu-Yeun Lee
Sep 6, 2014·The Journal of Antimicrobial Chemotherapy·Laurent PoirelPatrice Nordmann
Mar 4, 2015·Antimicrobial Agents and Chemotherapy·Aurélie JayolLaurent Poirel
Sep 19, 2015·Journal of Visualized Experiments : JoVE·Laura M KoethSandra McCurdy
Nov 26, 2015·The Lancet Infectious Diseases·Yi-Yun LiuJianzhong Shen
Jan 18, 2016·The Lancet Infectious Diseases·Marisa HaenniJean-Yves Madec
Jan 18, 2016·The Lancet Infectious Diseases·Laurent PoirelPatrice Nordmann
Mar 5, 2016·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Patrice NordmannLaurent Poirel
May 22, 2016·Infectious Disease Clinics of North America·Yohei DoiYoshichika Arakawa
Jun 15, 2016·Antimicrobial Agents and Chemotherapy·Ghady HaidarM Hong Nguyen
Jul 16, 2016·Euro Surveillance : Bulletin Européen Sur Les Maladies Transmissibles = European Communicable Disease Bulletin·Basil Britto XavierSurbhi Malhotra-Kumar
Mar 10, 2017·Clinical Microbiology Reviews·Laurent PoirelPatrice Nordmann
Jun 7, 2017·The Journal of Antimicrobial Chemotherapy·Aurélie JayolVéronique Dubois
Citations
Dec 20, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Maria S Ramirez, Marcelo E Tolmasky
Sep 13, 2018·Expert Review of Anti-infective Therapy·Matteo BassettiAlessandro Russo
Oct 31, 2018·Antimicrobial Agents and Chemotherapy·Andrew WalktyGeorge G Zhanel
Dec 5, 2018·Pharmacotherapy·Kristy M ShaeerJonathan C Cho
Jan 11, 2019·The Journal of Antimicrobial Chemotherapy·Mario JuhasSven N Hobbie
Jul 3, 2019·Journal of Clinical Medicine·Nicola PetrosilloGuido Granata
Jul 23, 2019·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Louis D Saravolatz, Gary E Stein
Dec 5, 2019·Expert Review of Anti-infective Therapy·Nicola PetrosilloFabrizio Taglietti
Feb 26, 2020·Antimicrobial Agents and Chemotherapy·Mariana CastanheiraRonald N Jones
Oct 30, 2019·Journal of Gastrointestinal Cancer·Aalaa Fahim AbbasMiaad K Alkhudhairy
Aug 20, 2019·Open Forum Infectious Diseases·Zekun LiQiwen Yang
Feb 7, 2019·Drugs·Khalid EljaalyJason M Pogue
Dec 25, 2019·International Microbiology : the Official Journal of the Spanish Society for Microbiology·Jindan Kai, Sheng Wang
Sep 25, 2020·Antimicrobial Resistance and Infection Control·Li YanShifeng Huang
Nov 1, 2018·Current Opinion in Infectious Diseases·Mario TumbarelloHelen Giamarellou
Jun 28, 2019·Frontiers in Public Health·Ilias KaraiskosGaryphallia Poulakou
Sep 3, 2020·Infection·Stamatis KarakonstantisAchilleas Gikas
Jun 4, 2020·Therapeutic Advances in Infectious Disease·Matteo Bassetti, Maddalena Peghin
Apr 4, 2021·Microorganisms·Corneliu Ovidiu VrancianuMariana Carmen Chifiriuc
Apr 4, 2021·Journal of Clinical Medicine·Erlangga YusufMireille van Westreenen
Jun 8, 2021·The Journal of Antimicrobial Chemotherapy·Brian D JohnstonJames R Johnson
Sep 4, 2021·Frontiers in Medicine·Firdoos Ahmad GogryQazi Mohd Rizwanul Haq