PLCε knockdown inhibits prostate cancer cell proliferation via suppression of Notch signalling and nuclear translocation of the androgen receptor

Cancer Letters
Yin WangChunLi Luo

Abstract

Phospholipase Cε (PLCε), a key regulator of diverse cellular functions, has been implicated in various malignancies. Indeed, PLCε functions include cell proliferation, apoptosis and malignant transformation. Here, we show that PLCε expression is elevated in prostate cancer (PCa) tissues compared to benign prostate tissues. Furthermore, PLCε depletion using an adenovirally delivered shRNA significantly decreased cell growth and colony formation, arresting the PC3 and LNCaP cell lines in the S phase of the cell cycle. We also observed that PLCε was significantly correlated with Notch1 and androgen receptor (AR). Additionally, we demonstrate that the activation of both the Notch and AR signalling pathways is involved in PLCε-mediated oncogenic effects in PCa. Our findings suggest that PLCε is a putative oncogene and prognostic marker, potentially representing a novel therapeutic target for PCa.

References

Jan 17, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Bilal Bin HafeezHasan Mukhtar
May 19, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Ricardo M AttarMarco M Gottardis
Jun 19, 2009·Advances in Enzyme Regulation·Tom D BunneyMatilda Katan
Jul 30, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Karen E Knudsen, Howard I Scher
Dec 8, 2009·Cancer Cell·Gerhardt AttardJohann S de Bono
Sep 28, 2010·Trends in Biochemical Sciences·Tom D Bunney, Matilda Katan
Dec 3, 2010·Cell Biology International·Yan LingZhang Qiaoling
Jan 31, 2012·Cellular Signalling·Alan V SmrckaGeorge G Holz
Aug 27, 2013·Cancer Letters·Ingrid Espinoza, Lucio Miele
Jan 9, 2014·CA: a Cancer Journal for Clinicians·Rebecca SiegelAhmedin Jemal
Apr 9, 2014·Neoplasia : an International Journal for Oncology Research·Shubing ZhangKeli Xu
Apr 17, 2014·The Prostate·Filipe L F CarvalhoDavid M Berman
Aug 20, 2014·Nature Reviews. Urology·Angela N FloresLaure Marignol

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Citations

Oct 21, 2017·Bioscience, Biotechnology, and Biochemistry·Jin YangXiao Gu
Aug 7, 2019·Journal of Experimental & Clinical Cancer Research : CR·Jiaxin FanChunli Luo

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