Pleiotrophin expression in human pancreatic cancer and its correlation with clinicopathological features, perineural invasion, and prognosis.

Digestive Diseases and Sciences
Jun YaoMin Zhang

Abstract

Pleiotrophin (PTN), a heparin-binding growth factor also known as neurite growth-promoting factor, exhibits several properties related with tumor development. PTN and its receptor, N-syndecan, may play a very important role in tumor growth and neural invasion of pancreatic cancer. We investigated PTN and N-syndecan protein levels in 38 patients with pancreatic cancer by immunohistochemistry, and analyzed for its correlation with clinicopathological features, perineural invasion, and prognosis. The results showed that PTN and N-syndecan proteins were found in 24 (63.2%) and 22 (57.9%) specimens, respectively. PTN and N-syndecan expressions were associated with perineural invasion (P = 0.016 and P = 0.029, respectively). High PTN expression was closely related to an advanced TNM stage (P = 0.007), lymph node metastasis (P = 0.040), and decreased postoperative survival at 3 years (50.0% versus 20.8%, respectively; P = 0.001). We conclude that high expression of PTN combined with N-syndecan may contribute to the increased perineural invasion and poor prognosis of pancreatic cancer.

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Citations

Oct 24, 2013·World Journal of Gastroenterology : WJG·Jun YaoShe-Gan Gao
Mar 25, 2014·World Journal of Gastroenterology : WJG·Jun YaoShe-Gan Gao
Jan 23, 2016·Biochimica Et Biophysica Acta·Dingkong LiangXianjun Yu
Feb 21, 2013·Expert Opinion on Therapeutic Targets·Sojoong ChoiEok-Soo Oh
Oct 25, 2016·Biochimica Et Biophysica Acta·Evangelia PapadimitriouDimitris Beis
Jan 1, 2010·Cancers·Ihsan Ekin DemirHelmut Friess

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