PMID: 11912283Mar 26, 2002Paper

Pleiotrophin (PTN) and midkine (MK) mRNA expression in eutopic and ectopic endometrium in advanced stage endometriosis

Molecular Human Reproduction
Hye Won ChungMary Lake Polan

Abstract

Endometriosis is characterized by the ectopic implantation of endometrium on peritoneal surfaces. Angiogenic and growth factors may play a significant role in the pathogenesis of endometriosis. Midkine (MK) and pleiotrophin (PTN) are two related peptides associated with carcinogenesis and angiogenesis. To test the hypothesis that a higher expression of MK and PTN in ectopic and eutopic endometrium from women with endometriosis might favour increased angiogenesis and growth with subsequent ectopic implantation, we investigated PTN and MK expression by quantitative competitive PCR (QC-PCR) in endometrium from 30 women with severe, stages III and IV endometriosis and from 30 women without endometriosis. Total RNA was extracted and reverse transcribed into cDNA, and QC-PCR was performed to evaluate PTN and MK mRNA expression. Results were analysed by analysis of variance. Eutopic endometrium from endometriosis patients showed increased expression of MK and PTN mRNA compared with endometrium from normal women in the luteal phase (P < 0.05). MK and PTN mRNA expression in ectopic endometrium was significantly lower than that in eutopic endometrium from women with and without endometriosis (P < 0.05). Our results suggest increased MK a...Continue Reading

Citations

Jun 16, 2011·Human Reproduction Update·K E MayC M Becker
Jun 22, 2012·Human Reproduction Update·M W Laschke, M D Menger
Jun 15, 2014·Reproductive Biology and Endocrinology : RB&E·Yana B AznaurovaAlex A Zhavoronkov
Jul 9, 2014·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Jinyang MaHuojun Hu
Jan 24, 2007·FEBS Letters·Dayong GuYaou Zhang
Jul 12, 2003·American Journal of Reproductive Immunology : AJRI·Ming-Yih Wu, Hong-Nerng Ho
Aug 5, 2014·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Mesut OktemPolat Dursun
Jul 15, 2016·Human Reproduction·K NirgianakisM Mueller
Apr 21, 2016·The Cochrane Database of Systematic Reviews·Devashana GuptaVicki Nisenblat
Aug 8, 2018·Reproductive Sciences·Kai WangZhan-Peng Yue
Oct 18, 2018·Biology of Reproduction·Nikola SekulovskiKanako Hayashi
Jul 15, 2020·Hormone Molecular Biology and Clinical Investigation·Michael OettelKlaus Nickisch
Mar 10, 2007·Human Reproduction Update·Matthias W Laschke, Michael D Menger
Feb 3, 2012·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Qiao-Ying Jiang, Rui-Jin Wu
Jan 30, 2018·Human Reproduction Update·Matthias W Laschke, Michael D Menger
Mar 1, 2005·Human Reproduction·Yasushi HirotaYuji Taketani
Sep 15, 2020·Hormone Molecular Biology and Clinical Investigation·Konstantinos NirgianakisMichael D Mueller

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