Pleiotropic Actions of FGF23

Toxicologic Pathology
Reinhold G Erben

Abstract

Fibroblast growth factor-23 (FGF23) is a bone-derived hormone, mainly produced by osteoblasts and osteocytes in response to increased extracellular phosphate and circulating vitamin D hormone. Endocrine FGF23 signaling requires co-expression of the ubiquitously expressed FGF receptor 1 (FGFR1) and the co-receptor α-Klotho (Klotho). In proximal renal tubules, FGF23 suppresses the membrane expression of the sodium-phosphate cotransporters Npt2a and Npt2c which mediate urinary reabsorption of filtered phosphate. In addition, FGF23 suppresses proximal tubular expression of 1α-hydroxylase, the key enzyme responsible for vitamin D hormone production. In distal renal tubules, FGF23 signaling activates with-no-lysine kinase 4, leading to increased renal tubular reabsorption of calcium and sodium. Therefore, FGF23 is not only a phosphaturic but also a calcium- and sodium-conserving hormone, a finding that may have important implications for the pathophysiology of chronic kidney disease. Besides these endocrine, Klotho-dependent functions of FGF23, FGF23 is also an auto-/paracrine suppressor of tissue-nonspecific alkaline phosphatase transcription via Klotho-independent FGFR3 signaling, leading to local inhibition of mineralization throu...Continue Reading

References

May 10, 2001·Proceedings of the National Academy of Sciences of the United States of America·T ShimadaT Yamashita
Jul 12, 2003·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Thomas J WeberL Darryl Quarles
Mar 26, 2004·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Takashi ShimadaTakeyoshi Yamashita
Dec 8, 2004·Matrix Biology : Journal of the International Society for Matrix Biology·Despina SitaraBeate Lanske
Mar 25, 2005·American Journal of Physiology. Cell Physiology·Nadine DéliotHeini Murer
Jul 7, 2005·American Journal of Physiology. Renal Physiology·Takashi ShimadaTakeyoshi Yamashita
Jul 21, 2005·The Journal of Clinical Endocrinology and Metabolism·Kaori ArayaToshiro Fujita
Nov 7, 2006·Nature·Itaru UrakawaTakeyoshi Yamashita
Nov 25, 2006·Matrix Biology : Journal of the International Society for Matrix Biology·Martina HesseReinhold G Erben
Mar 14, 2007·Bone·Yuji YoshikoNorihiko Maeda
Aug 22, 2007·The Journal of Clinical Investigation·Shoji IchikawaMichael J Econs
May 12, 2009·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Majd A I MirzaTobias E Larsson
Jun 12, 2009·American Journal of Physiology. Renal Physiology·Jyothsna GattineniMichel Baum
May 29, 2010·Clinical Journal of the American Society of Nephrology : CJASN·Orlando M Gutiérrez
Apr 8, 2011·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Daniel RanchFarzana Perwad
Jun 16, 2011·JAMA : the Journal of the American Medical Association·Tamara IsakovaUNKNOWN Chronic Renal Insufficiency Cohort (CRIC) Study Group
Oct 12, 2011·The Journal of Clinical Investigation·Christian FaulMyles Wolf
Feb 3, 2012·Physiological Reviews·Aline MartinL Darryl Quarles
Mar 28, 2012·Molecular and Cellular Biology·Regina GoetzMoosa Mohammadi
Jun 27, 2012·The Journal of Biological Chemistry·Regina GoetzMoosa Mohammadi
Dec 13, 2012·American Journal of Physiology. Endocrinology and Metabolism·Stephen J QuinnEdward M Brown
Feb 8, 2013·Kidney International·Julia J SciallaUNKNOWN Chronic Renal Insufficiency Cohort Study Investigators
Apr 12, 2013·PloS One·Karolina LindbergTobias E Larsson
Oct 26, 2013·Journal of the American Society of Nephrology : JASN·Julia J SciallaUNKNOWN Chronic Renal Insufficiency Cohort (CRIC) Study Investigators
Mar 29, 2014·Clinical Journal of the American Society of Nephrology : CJASN·Sarah SeilerGunnar H Heine
Apr 8, 2014·Proceedings of the National Academy of Sciences of the United States of America·Vincent S TagliabracciJack E Dixon
May 7, 2014·EMBO Molecular Medicine·Olena AndrukhovaReinhold G Erben
May 29, 2014·Current Opinion in Nephrology and Hypertension·Myles Wolf, Kenneth E White
Jun 19, 2014·Kidney International·Tomer MeirTally Naveh-Many
Jul 24, 2014·American Journal of Physiology. Endocrinology and Metabolism·Neerupma SilswalMichael J Wacker
Aug 5, 2014·PloS One·Zhousheng XiaoLeigh Darryl Quarles
Dec 3, 2014·Molecular and Cellular Endocrinology·Nobuaki ItoGerald J Atkins
Mar 6, 2015·Biological & Pharmaceutical Bulletin·Yuki MasudaMorichika Konishi

❮ Previous
Next ❯

Citations

Jun 1, 2018·Current Opinion in Nephrology and Hypertension·Reinhold G Erben
Jul 18, 2020·Current Osteoporosis Reports·Wei CaoEngelbert A J M Schulten
Nov 20, 2019·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Kelsey A Carpenter, Ryan D Ross
Aug 30, 2019·International Journal of Molecular Sciences·Brian Czaya, Christian Faul
May 7, 2019·Frontiers in Pediatrics·Yao LinMingming Zhang
Jun 13, 2018·Frontiers in Endocrinology·Maren Leifheit-Nestler, Dieter Haffner
Aug 14, 2019·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·T RuppT Rolvien
May 18, 2018·Frontiers in Endocrinology·Beatrice Richter, Christian Faul
Dec 13, 2019·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Bar Rotem-Grunbaum, Daniel Landau
Jan 11, 2020·Frontiers in Endocrinology·Yi LiLicheng Zhang
May 1, 2021·International Journal of Molecular Sciences·Matthias MährNadja Fratzl-Zelman
May 22, 2021·Bone Research·Ruoyu ZhouXianghang Luo

❮ Previous
Next ❯

Methods Mentioned

BETA
glycosylation

Related Concepts

Related Feeds

Calcium & Bioenergetics

Bioenergetic processes, including cellular respiration and photosynthesis, concern the transformation of energy by cells. Here is the latest research on the role of calcium in bioenergetics.

Related Papers

Current Opinion in Nephrology and Hypertension
Reinhold G Erben, Olena Andrukhova
Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research
Harald JüppnerI B Salusky
Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research
Sathish K MuraliReinhold G Erben
Molecular and Cellular Endocrinology
Reinhold G Erben
© 2022 Meta ULC. All rights reserved