PMID: 7035172Jan 1, 1982Paper

Pleiotropic deficiency in nitrogen-uptake systems and derepression of nitrogen-catabolic enzymes in npr-1 mutants of Saccharomyces cerevisiae

European Journal of Biochemistry
M Grenson, E Dubois

Abstract

The npr-1 mutation has two types of effects in Saccharomyces cerevisiae. On one hand, several nitrogen-catabolic enzymes are derepressed in the presence of ammonia, glutamine, or asparagine, which provoke their repression in a wild-type strain. On the other hand, the activity of several ammonia-sensitive permeases is decreased (from 50-100% depending on the permease considered) in npr-1 cells, independently of the nitrogen source used for growth. Our results favour the idea that the primary effect of the npr-1 mutation is on the permeases, and that the derepression of the enzymes is a consequence of the reduced uptake rate of the repressing nitrogen compounds. Hence, the product of the npr-1 gene appears to be directly involved in the development of the activity of a set of permeases which transport nitrogen compounds and which are regulated by nitrogen effectors.

References

Mar 21, 1977·Biochemical and Biophysical Research Communications·E DuboisJ M Wiame
Aug 1, 1979·Molecular & General Genetics : MGG·E Dubois, M Grenson
Dec 1, 1975·Biochemical and Biophysical Research Communications·C Darte, M Grenson
Jan 1, 1972·Journal of Bacteriology·R Drillien, F Lacroute
Mar 11, 1969·Biochimica Et Biophysica Acta·J Schwencke, N Magaña-Schwencke

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Citations

Jan 1, 1995·FEMS Microbiology Reviews·V Sophianopoulou, G Diallinas
Jan 21, 2000·FEMS Microbiology Reviews·E G ter SchureC T Verrips
Apr 17, 2018·International Journal of Molecular Sciences·Bruno André
Aug 31, 2012·Microbiology and Molecular Biology Reviews : MMBR·Robert A Bender
Nov 30, 2016·The Journal of Biological Chemistry·Cecilia PrimoLynne Yenush
Dec 22, 1986·Biochimica Et Biophysica Acta·J Horák

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