Pleiotropic effects of LDL apheresis

Atherosclerosis. Supplements
A RamunniP Brescia

Abstract

LDL apheresis (LA), a technique employed to remove atherogenic lipoproteins, has been shown to exert a protective function on the vessel walls. This effect can be attributed to pleiotropic mechanisms that safeguard against endothelial dysfunction by reducing the concentrations of pro-inflammatory and pro-coagulation markers. Besides these actions, LA improves whole blood viscosity and endothelium-mediated vasodilation, and has a positive effect on the hemorheological picture, improving perfusion in the microcirculation. Although the short term effects on the functional component of the vascular damage seem to be temporary, long term effects on the morphological alterations have also been shown. It is still not clear which of the many proposed actions, or others still to be discovered, is the principal vessel protective mechanism.

References

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Citations

Apr 25, 2012·Clinical Research in Cardiology Supplements·Alfonso RamunniLoreto Gesualdo
May 21, 2014·Best Practice & Research. Clinical Endocrinology & Metabolism·Michael M PageJohn R Burnett
Jan 30, 2013·Atherosclerosis. Supplements·Alfonso RamunniPaola Brescia
Jan 30, 2013·Atherosclerosis. Supplements·Marat V EzhovSergei N Pokrovsky
May 26, 2015·Current Atherosclerosis Reports·Vijay G Bhoj, Bruce S Sachais
Jul 15, 2016·Therapeutic Apheresis and Dialysis : Official Peer-reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy·Takayasu OhtakeShuzo Kobayashi
Feb 23, 2020·Journal of Clinical Apheresis·Lucia MerolleThelma A Pertinhez
Mar 7, 2019·Clinical Research in Cardiology Supplements·V J J SchettlerUNKNOWN Scientific Board of GLAR for the German Apheresis Working Group
Apr 20, 2021·Journal of Atherosclerosis and Thrombosis·Atsushi NoharaMariko Harada-Shiba

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