Pleiotropic effects of regular lipoprotein-apheresis

Atherosclerosis. Supplements
Helmut SinzingerK Derfler

Abstract

Lipoprotein(LP)-apheresis is the treatment of choice in patients suffering from severe familial hypercholesterolemia. A wide range of mechanisms has been claimed to be responsible for the known clinical benefit. Patients suffering from heterozygous familial hypercholesterolemia undergoing LP-apheresis either with direct adsorption of lipoproteins (DALI) or dextran sulfate (DS) were examined. A total volume of 10 l blood was exchanged. Non-lipid effects, mainly concerning endothelial function (circulating endothelial cells, circulating endothelial progenitor cells, flow-mediated vasodilation, microalbuminuria) as well as left ventricular ejection fraction and homocysteine were assessed. A single LP-apheresis session improves paradox contractile response in statin intolerant patients, but not in those on regular statin therapy. In contrast, over a 6-months follow-up after treatment initiation, all the examined parameters (circulating endothelial cells, circulating endothelial progenitor cells, flow mediated vasodilatation, homocysteine, microalbuminuria and left ventricular ejection fraction) improved. When available, a comparison between DS vs. DALI was performed. In none of the subgroups a significant difference was noted. Thes...Continue Reading

Citations

Nov 30, 2019·Journal of Clinical Apheresis·Randolf HardersenAnders Hovland
Dec 7, 2018·European Journal of Preventive Cardiology·Ivana VeljićPetar M Seferović
Aug 7, 2021·Biomedicines·Gabriella IannuzzoMarco Gentile
Dec 11, 2019·Atherosclerosis. Supplements·Georgiana-Aura GiurgeaHelmut Sinzinger

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