PMID: 26343116Sep 8, 2015Paper

Pleiotropic Effects of Tocotrienols and Quercetin on Cellular Senescence: Introducing the Perspective of Senolytic Effects of Phytochemicals

Current Drug Targets
Marco MalavoltaMauro Provinciali

Abstract

The possibility to target cellular senescence with natural bioactive substances open interesting therapeutic perspective in cancer and aging. Engaging senescence response is suggested as a key component for therapeutic intervention in the eradication of cancer. At the same time, delaying senescence or even promote death of accumulating apoptosis-resistant senescent cells is proposed as a strategy to prevent age related diseases. Although these two desired outcome present an intrinsic dichotomy, there are examples of promising natural compounds that appear to satisfy all the requirements to develop senescence- targeted health promoting nutraceuticals. Tocotrienols (T3s) and quercetin (QUE), albeit belonging to different phytochemical classes, display similar and promising effects "in vitro" when tested in normal and cancer cells. Both compounds have been shown to induce senescence and promote apoptosis in a multitude of cancer lines. Conversely, they display senescence delaying activity in primary cells and rejuvenating effects in senescent cells. More recently, QUE has been shown to display senolytic effects in some primary senescent cells, likely as a consequence of its inhibitory effects on specific anti-apoptotic genes (i.e....Continue Reading

Citations

Sep 15, 2016·Critical Reviews in Food Science and Nutrition·Rúbia C G CorrêaIsabel C F R Ferreira
Aug 2, 2018·Journal of Cellular Physiology·Marina Montagnani MarelliPatrizia Limonta
Mar 8, 2016·BioFactors·Leanne De SilvaJu-Yen Fu
Apr 8, 2020·Equine Veterinary Journal·E KellyR G A Faragher
Apr 9, 2017·Pflügers Archiv : European journal of physiology·Roland Schmitt
Oct 23, 2019·Nature Communications·Francisco Triana-MartínezManuel Collado
Oct 27, 2020·Stem Cells International·Provvidenza M AbruzzoCarlo Ventura
Jan 5, 2021·Annals of Geriatric Medicine and Research·Gulperi Yalcin, Cheol-Koo Lee
May 1, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Stanislav SukhikhOlga Babich

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