Pleiotropic Immune Functions of Chemokine Receptor 6 in Health and Disease

Medicines
Ranmali Ranasinghe, Rajaraman Eri

Abstract

C-C chemoattractant cytokine (chemokine) receptor 6 (CCR6) and its exclusive binding molecule CCL20 is an extremely important chemokine receptor-ligand pair which controls cell migration and immune induction during inflammatory disease. Not many scientific studies have been undertaken to study its immune mechanisms in detail, but its unique contribution to steady state cell chemotaxis in upholding immune tolerance and regulating immune homeostasis during inflammation is evident in multiple systems in the human body, including skin, liver, lung, kidney, brain, eye, joints, gonads and the gut. The role of CCR6 is constitutively expressed as a series of much debilitating severe inflammatory and autoimmune diseases, Human Immunodeficiency Virus (HIV) and cancer metastasis. CD4⁺ T cells, the central organizers of adaptive immunity, are stringently mobilized by the CCR6/CCL20 axis also induced by cytokines and a host of other factors in a carefully executed immune modulation scenario, to bring about a delicate balance between inflammation inducing TH17 cells and regulatory Treg cells. Although the exact immune regulatory role is not elucidated as yet, the CCR6/CCL20 axis is implicated as a front runner which determines the polarizati...Continue Reading

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Citations

Jul 18, 2019·Journal of the American Society of Nephrology : JASN·Julia HagensteinOliver M Steinmetz
Feb 8, 2020·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Sara Abouelasrar SalamaJo Van Damme
Apr 18, 2020·Scientific Reports·Indoumady BaskaraSabine Le Gouvello
Jun 4, 2021·Arthritis & Rheumatology·Zhenrui ShiSam T Hwang

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Methods Mentioned

BETA
nucleotide exchange
phage-display
biopsies
contraception
PCA

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